Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/18749
Title: Prevalence and Incidence of HCV Infection among Prisoners in Central Brazil
Authors: Puga, Marco Antonio Moreira
Bandeira, Larissa Melo
Pompilio, Mauricio Antonio
Croda, Julio
Rezende, Grazielli Rocha de
Dorisbor, Luiz Fernando Paiva
Tanaka, Tayana Serpa Ortiz
Cesar, Gabriela Alves
Teles, Sheila Araújo
Simionatto, Simone
Novais, Alisson Richard Teixeira
Nepomuceno, Bruna
Castro, Lisie Souza
Lago, Barbara Vieira do
Castro, Ana Rita Coimbra Mota
Affilliation: Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Mato Grosso do Sul, MS. Brasil / Universidade Federal do Grande Dourados. Mato Grosso do Sul, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Universidade Federal de Goiás. Escola de Enfermagem. Goiânia, GO, Brasil.
Universidade Federal do Grande Dourados.. Mato Grosso do Sul, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Mato Grosso do Sul, MS, Brasil.
Abstract: The aim of this multicenter, cross sectional study was to assess the prevalence, incidence and associated risk factors among incarcerated populations from twelve Brazilian prisons. The total of 3,368 individuals from twelve prisons was randomly recruited between March 2013 and March 2014. Participants were interviewed, and provided blood samples which were tested for antibodies to Hepatitis C (HCV ab). One year after the first investigation, a cohort study was conducted with 1,656 inmates who participated the cross sectional study. Positive samples were tested for the presence of HCV RNA. Out of 3,368 inmates, 520 (15.4%) were females, and 2,848 (84.6%) were males. The overall prevalence of HCV was 2.4% (95% CI: 1.9 to 2.9), with 0.6% (95% CI: 0.4 to 0.8) in females, and 2.7% (95% CI: 2.1 to 3.3) in males (p<0.01). HCV RNA was detected in 51/80 (63.7%) samples. Among men prisoners, multivariate analysis of associated factors showed independent associations between HCV exposure and increasing age, inject drug use, length of incarceration, smoking hashish, sharing needle and syringe and HIV positivity. During the cohort study, 7/1,656 new cases of HCV infection were detected, and the incidence rate was 0.4/100 person-year. Once high frequency rates of specific HCV risk behaviors and new HCV infections have been identified inside prisons, effective interventions strategies such as screening, clinical evaluation and treatment to reduce the spread of HCV infection are essential.
Keywords: HCV Infection
Prisoners
Central Brazil
Prevalence
Incidence
cross sectional study
keywords: Hepacivirus
Infecção
Brasil Central
Prevalência
Incidência
Prisioneiros
Estudo transversal
Issue Date: 2017
Publisher: Public Library of Science
Citation: PUGA, Marco Antonio Moreira; et al. Prevalence and Incidence of HCV Infection among Prisoners in Central Brazil. PLoS ONE, v.12, n.1, e0169195, 14p, 2017.
DOI: 10.1371/journal.pone.0169195
ISSN: 1932-6203
Copyright: open access
Appears in Collections:MS - Artigos de Periódicos
IOC - Artigos de Periódicos

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