Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/18807
Title: Antiparasitical chemotherapy in Chagas' disease cardiomyopathy: current evidence
Authors: Guedes, Paulo Marcos Matta
Gutierrez, Fredy Roberto Salazar
Nascimento, Manuela Sales Lima
Matta, Maria Adelaide do Valle
Silva, João Santana
Affilliation: Universidade Federal do Rio Grande do Norte. Centro de Biociências. Departamento de Microbiologia e Parasitologia. Natal, RN, Brasil.
University Antonio Nariño. School of Medicine. Bogotá, Colombia.
Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ. Brasil.
Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.
Abstract: Chronic chagasic cardiomyopathy affects 20% of Chagas' disease patients. At present, Chagas' disease chemotherapy uses nitrofurans, benznidazole (Rochagan®, Rodanil®, Roche) or nifurtimox (Lampit®, Bayer). Treatment during acute and recent chronic phases in childhood effects 71.5% and 57.6%, respectively, of parasitological cure. However, in clinical trials during the late chronic phase, only 5.9% of parasitological cure were achieved. This review focuses on the benefit from aetiological treatment to avoid, stop or revert myocarditis. Divergent data gathered from clinical practice are not convincing to support prescription of aetiological treatment as routine for indeterminate and cardiac chronic patients.
Keywords: Trypanosoma cruzi
Chagas Disease
chemotherapy
parasite persistence
cardiac inflammation
keywords: Trypanosoma cruzi
Doença de Chagas
Quimioterapia
Persistência do parasita
Inflamação cardíaca
Issue Date: 2012
Publisher: Wiley
Citation: GUEDES, Paulo Marcos Matta; et al. Antiparasitical chemotherapy in Chagas’ disease cardiomyopathy: current evidence. Tropical Medicine and International Health, v.17, n.9, p.1057-1065, Sept. 2012.
DOI: 10.1111/j.1365-3156.2012.03025.x
ISSN: 1360-2276
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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