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THE BALANCE BETWEEN THE SERUM LEVELS OF IL-6 AND IL-10 CYTOKINES DISCRIMINATES MILD AND SEVERE ACUTE PNEUMONIA
Pneumonia / sangue
Contagem de Leucócitos
Biomarcadores / sangue
Estudos Prospectivos
Author
Affilliation
Institute of Integral Medicine Professor Fernando Figueira (IMIP). Pediatrics. Recife, PE, Brazil.
Institute of Integral Medicine Professor Fernando Figueira (IMIP). Oncology and Aggeu Magalhães Research Center. Fiocruz-PE. Immunology. Recife, PE, Brazil.
Institute of Integral Medicine Professor Fernando Figueira ( IMIP). Translational Medicine Laboratory. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Pública. Recife, PE, Brasil.
Institute of Integral Medicine Professor Fernando Figueira ( IMIP). Translational Medicine Laboratory. Recife, PE, Brazil.
Federal University of Pernambuco. Pediatrics. Recife, PE, Brazil.
Institute of Integral Medicine Professor Fernando Figueira (IMIP). Oncology and Aggeu Magalhães Research Center. Fiocruz-PE. Immunology. Recife, PE, Brazil.
Institute of Integral Medicine Professor Fernando Figueira ( IMIP). Translational Medicine Laboratory. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Pública. Recife, PE, Brasil.
Institute of Integral Medicine Professor Fernando Figueira ( IMIP). Translational Medicine Laboratory. Recife, PE, Brazil.
Federal University of Pernambuco. Pediatrics. Recife, PE, Brazil.
Abstract
Background: To identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between
serum cytokine profile of children with different pneumonia severity.
Methods: In 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration
of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests,
Pearson correlation and ROC curve for cut-off definition of cytokines.
Results: At admission, IL-6 serum levels were high in mild or severe pneumonia, and was associated to vomiting (P = 0.
019) in both groups; and also to dyspnea (P = 0.012) and white blood cell count (P = 0.045) in patients with severe
pneumonia. IL-10 levels were also high in patients with pneumonia and were associated to lymphocytosis (P = 0.025).
The ROC curve of the IL-6:IL-10 serum levels ratio discriminated severe pneumonia cases at admission, and persistence
of infection in the third day of antibiotic therapy, with positive predictive values of 93% and 89%, respectively.
Conclusions: The balance between IL-6 and IL-10 serum levels showed to be a more discriminative marker for severity
definition and evaluation of recovery in patients with pneumonia.
DeCS
Interleucina-10 / sanguePneumonia / sangue
Contagem de Leucócitos
Biomarcadores / sangue
Estudos Prospectivos
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