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FULL GENOME SEQUENCE AND SFRNA INTERFERON ANTAGONIST ACTIVITY OF ZIKA VIRUS FROM RECIFE, BRAZIL
Donald, Claire L. et al. | Date Issued: 2016
Author
Donald, Claire L.
Brennan, Benjamin
Cumberworth, Stephanie L.
Rezelj, Veronica V.
Clark, Jordan J.
Cordeiro, Marli T.
França, Rafael Freitas de Oliveira
Pena, Lindomar J.
Wilkie, Gavin S.
Filipe, Ana da Silva
Davis, Christopher
Hughes, Joseph
Varjak, Margus
Selinger, Martin
Zuvanov, Luíza
Owsianka, Ania M.
Patel, Arvind H.
McLauchlan, John
Lindenbach, Brett D.
Fall, Gamou
Sall, Amadou A.
Biek, Roman
Rehwinkel, Jan
Schnettler, Esther
Kohl, Alain
Affilliation
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
University of South Bohemia. Faculty of Science. Česke´ Budějovice, Czech Republic / Institute of Parasitology. Biology Centre of the Academy of Sciences of the Czech Republic. Česke´ Budějovice, Czech Republic.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
Yale University. Department of Microbial Pathogenesis. New Haven, Connecticut, United States of America.
Institut Pasteur de Dakar. Pole de Virologie. Unité des arbovirus et virus des fièvres hémorragiques. Dakar, Senegal.
Institut Pasteur de Dakar. Pole de Virologie. Unité des arbovirus et virus des fièvres hémorragiques. Dakar, Senegal.
University of Glasgow. Institute of Biodiversity, Animal Health and Comparative Medicine. Boyd Orr Centre for Population and Ecosystem Health. College of Medical Veterinary and Life Sciences. Glasgow, Scotland, United Kingdom.
University of Oxford. Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine and Radcliffe Department of Medicine. Oxford, England, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, United Kingdom.
Abstract
The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern. Little is currently known about the evolution and biology of ZIKV and the factors that contribute to the associated pathogenesis. Determining genomic sequences of clinical viral isolates and characterization of elements within these are an important prerequisite to advance our understanding of viral replicative processes and virus-host interactions.
Keywords in Portuguese
Surtos de Doenças
Zika Vírus
Células A549
 
DeCS
Genoma Viral
Interferon tipo I / antagonistas e inibidores
RNA Viral / genética
Vírus Zika / isolamento e purificação
Zika a infecção pelo vírus / virologia
 
Citation
DONALD, C. L. et al. Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil. PLOS Neglected Tropical Diseases, v. 10, n. 10, p. e0005048, 5 out. 2016.
DOI
10.1371/journal.pntd.0005048
ISSN
1935-2735