| Author | Santos, Hayna Malta | |
| Author | Andrade, Bruno de Bezerril | |
| Author | Zanette, Dalila Lucíola | |
| Author | Costa, Jackson Mauricío | |
| Author | Bozza, Patrícia T. | |
| Author | Melo, Christianne Bandeira | |
| Author | Barral, Aldina Maria Prado | |
| Author | Costa, Jaqueline França | |
| Author | Borges, Valeria de Matos | |
| Access date | 2017-05-18T13:47:17Z | |
| Available date | 2017-05-18T13:47:17Z | |
| Document date | 2017 | |
| Citation | SANTOS, H. M. et al. Resolvin D1 drives establishment of Leishmania amazonensis infection. Scientific Reports, v. 7, p. 46363, 2017. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18964 | |
| Sponsorship | Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V. M. B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V. M. B.) | pt_BR |
| Language | eng | pt_BR |
| Publisher | Nature Publishing Group | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmania amazonensis | pt_BR |
| Subject in Portuguese | Leishmania | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | Eicosanóides | pt_BR |
| Subject in Portuguese | Mediadores lipídicos | pt_BR |
| Title | Resolvin D1 drives establishment of Leishmania amazonensis infection | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1038/srep46363 | |
| Abstract | Previous studies have indicated that the balance between different eicosanoids reflect the intensity of the inflammatory profile in patients with tegumentary leishmaniasis. More recently, pro-resolution lipid mediators have been shown to play critical roles in dampening pathological inflammatory processes to reestablish homeostasis in a diverse range of experimental settings. Among these lipid mediator, resolvins from D series have been described as potent anti-inflammatory and immunomodulatory mediators, and its activities include inhibition of leukocyte chemotaxis and blockage production of proinflammatory cytokines, while increasing the expression of regulatory mediators. Whether resolvins play significant roles in establishment and persistence of Leishmania infection is currently unknown. We addressed this question in the current study by assessing circulating levels of D-series resolvins in tegumentary leishmaniasis patients presenting with localized or diffuse disease. We found heightened expression of resolvin D1 in diffuse cutaneous leishmaniasis which was correlated with expression profile of biomarkers associated with disease pathogenesis. Additional in vitro experiments using primary human macrophages indicated that resolvin D1 may promote intracellular Leishmania amazonensis replication through a mechanism associated with induction of heme oxygenase-1. These results suggest that targeting resolvin D1 could serve as potential strategy for host directed therapy in diffuse cutaneous leishmaniasis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Subject | Leishmania amazonensis | pt_BR |
| Subject | Leishmania | pt_BR |
| Subject | Infection | pt_BR |
| Subject | Eicosanoids | pt_BR |
| DeCS | Leishmania Mexicana Amazonensis | pt_BR |
| DeCS | Leishmaniose Tegumentar Americana | pt_BR |
| DeCS | Infecção | pt_BR |
| DeCS | Eicosanóides | pt_BR |
| DeCS | Mediadores lipídicos | pt_BR |
