Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/18964
Title: Resolvin D1 drives establishment of Leishmania amazonensis infection
Authors: Santos, Hayna Malta
Andrade, Bruno de Bezerril
Zanette, Dalila Lucíola
Costa, Jackson Mauricío
Bozza, Patrícia Torres
Melo, Christianne Bandeira
Barral, Aldina Maria Prado
Costa, Jaqueline França
Borges, Valéria de Matos
Affilliation: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Abstract: Previous studies have indicated that the balance between different eicosanoids reflect the intensity of the inflammatory profile in patients with tegumentary leishmaniasis. More recently, pro-resolution lipid mediators have been shown to play critical roles in dampening pathological inflammatory processes to reestablish homeostasis in a diverse range of experimental settings. Among these lipid mediator, resolvins from D series have been described as potent anti-inflammatory and immunomodulatory mediators, and its activities include inhibition of leukocyte chemotaxis and blockage production of proinflammatory cytokines, while increasing the expression of regulatory mediators. Whether resolvins play significant roles in establishment and persistence of Leishmania infection is currently unknown. We addressed this question in the current study by assessing circulating levels of D-series resolvins in tegumentary leishmaniasis patients presenting with localized or diffuse disease. We found heightened expression of resolvin D1 in diffuse cutaneous leishmaniasis which was correlated with expression profile of biomarkers associated with disease pathogenesis. Additional in vitro experiments using primary human macrophages indicated that resolvin D1 may promote intracellular Leishmania amazonensis replication through a mechanism associated with induction of heme oxygenase-1. These results suggest that targeting resolvin D1 could serve as potential strategy for host directed therapy in diffuse cutaneous leishmaniasis.
Keywords: Leishmania amazonensis
Leishmania
Infection
Eicosanoids
keywords: Leishmania amazonensis
Leishmania
Infecção
Eicosanóides
Mediadores lipídicos
DeCS: Leishmania Mexicana Amazonensis
Leishmaniose Tegumentar Americana
Infecção
Eicosanóides
Mediadores lipídicos
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: SANTOS, H. M. et al. Resolvin D1 drives establishment of Leishmania amazonensis infection. Scientific Reports, v. 7, p. 46363, 2017.
DOI: 10.1038/srep46363
ISSN: 2045-2322
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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