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AutorMetsky, Hayden C.
AutorMatranga, Christian B.
AutorWohl, Shirlee
AutorSchaffner, Stephen F.
AutorFreije, Catherine A.
AutorWinnicki, Sarah M.
AutorWest, Kendra
AutorQu, James
AutorBaniecki, Mary Lynn
AutorGladden-Young, Adrianne
AutorLin, Aaron E.
AutorTomkins-Tinch, Christopher H.
AutorYe, Simon H.
AutorPark, Daniel J.
AutorLuo, Cynthia Y.
AutorBarnes, Kayla G.
AutorShah, Rickey R.
AutorChak, Bridget
AutorLima, Giselle Barbosa
AutorDelatorre, Edson
AutorVieira, Yasmine R.
AutorPaul, Lauren M.
AutorTan, Amanda L.
AutorBarcellona, Carolyn M.
AutorPorcelli, Mario C.
AutorVasquez, Chalmers
AutorCannons, Andrew C.
AutorCone, Marshall R.
AutorHogan, Kelly N.
AutorKopp, Edgar W.
AutorAnzinger, Joshua J.
AutorGarcia, Kimberly F.
AutorParham, Leda A.
AutorRamírez, Rosa M Gélvez
AutorMontoya, Maria C. Miranda
AutorRojas, Diana P.
AutorBrown, Catherine M.
AutorHennigan, Scott
AutorSabina, Brandon
AutorScotland, Sarah
AutorGangavarapu, Karthik
AutorGrubaugh, Nathan D.
AutorOliveira, Glenn
AutorRobles-Sikisaka, Refugio
AutorRambaut, Andrew
AutorGehrke, Lee
AutorSmole, Sandra
AutorHalloran, M. Elizabeth
AutorVillar, Luis
AutorMattar, Salim
AutorLorenzana, Ivette
AutorCerbino Neto, José
AutorValim, Clarissa
AutorDegrave, Wim
AutorBozza, Patrícia T.
AutorGnirke, Andreas
AutorAndersen, Kristian G.
AutorIsern, Sharon
AutorMichael, Scott F.
AutorBozza, Fernando A.
AutorSouza, Thiago Moreno L.
AutorBosch, Irene
AutorYozwiak, Nathan L.
AutorMacInnis, Bronwyn L.
AutorSabeti, Pardis C.
Fecha de acceso2017-06-01T13:40:34Z
Fecha de disponibilización2017-06-01T13:40:34Z
Fecha de publicación2017
ReferenciaMETSKY, Hayden C. et al. Zika virus evolution and spread in Americas. Nature, v. 546, n. 7658, p. 411-415, June 2017.pt_BR
ISSN0028-0836pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/19083
DescripciónO artigo encontra-se disponível para download no site do Editor.pt_BR
Idiomaengpt_BR
EditorNature Publishing Grouppt_BR
Versión posteriorhttps://www.arca.fiocruz.br/handle/icict/29542
Derechos de autoropen access
Palabras clave en PortuguésZika viruspt_BR
Palabras clave en PortuguésEvoluçãopt_BR
Palabras clave en PortuguésAméricaspt_BR
TítuloZika virus evolution and spread in the Americaspt_BR
Tipo del documentoArticle
DOI10.1038/nature22402
Resumen en InglésAlthough the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA / Harvard University. Harvard T.H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Massachusetts Institute of Technology. Harvard-MIT Health Sciences and Technology. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA / Harvard University. Harvard T.H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University Extension Schoo. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFlorida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.pt_BR
AfiliaciónFlorida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.pt_BR
AfiliaciónFlorida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.pt_BR
AfiliaciónMiami-Dade County Mosquito Control. Miami, Florida, USA.pt_BR
AfiliaciónMiami-Dade County Mosquito Control. Miami, Florida, USA.pt_BR
AfiliaciónFlorida Department of Health. Division of Disease Control and Health Protection. Bureau of Public Health Laboratories. Tampa, Florida, USA.pt_BR
AfiliaciónFlorida Department of Health. Division of Disease Control and Health Protection. Bureau of Public Health Laboratories. Tampa, Florida, USA.pt_BR
AfiliaciónFlorida Department of Health. Division of Disease Control and Health Protection. Bureau of Public Health Laboratories. Tampa, Florida, USA.pt_BR
AfiliaciónFlorida Department of Health. Division of Disease Control and Health Protection. Bureau of Public Health Laboratories. Tampa, Florida, USA.pt_BR
AfiliaciónThe University of the West Indies. Department of Microbiology. Mona, Kingston, Jamaica.pt_BR
AfiliaciónUniversidad Nacional Autónoma de Honduras. Instituto de Investigacion en Microbiologia. Tegucigalpa, Honduras.pt_BR
AfiliaciónUniversidad Nacional Autónoma de Honduras. Instituto de Investigacion en Microbiologia. Tegucigalpa, Honduras.pt_BR
AfiliaciónUniversidad Industrial de Santander. Grupo de Epidemiología Clínica. Bucaramanga, Colombia.pt_BR
AfiliaciónUniversidad Industrial de Santander. Grupo de Epidemiología Clínica. Bucaramanga, Colombia.pt_BR
AfiliaciónUniversity of Florida. College of Public Health and Health Professions. Department of Epidemiology. Gainesville, Florida, USA.pt_BR
AfiliaciónMassachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.pt_BR
AfiliaciónMassachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.pt_BR
AfiliaciónMassachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.pt_BR
AfiliaciónMassachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.pt_BR
AfiliaciónThe Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, California, USA..pt_BR
AfiliaciónThe Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, California, USA..pt_BR
AfiliaciónScripps Translational Science Institute. La Jolla, California, USA.pt_BR
AfiliaciónThe Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, California, USA..pt_BR
AfiliaciónUniversity of Edinburgh. Institute of Evolutionary Biology. Edinburgh EH9 3FL, UK / National Institutes of Health. Fogarty International Center. Bethesda, Maryland, USA.pt_BR
AfiliaciónMassachusetts Institute of Technology. Institute for Medical Engineering and Science. Cambridge, Massachusetts, USA / Harvard Medical School. Department of Microbiology and Immunobiology. Boston, Massachusetts, USA.pt_BR
AfiliaciónMassachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.pt_BR
AfiliaciónFred Hutchinson Cancer Research Center, Seattle. Vaccine and Infectious Disease Division. Seattle, Washington, USA / University of Washington. Department of Biostatistics. Seattle, Washington, USA.pt_BR
AfiliaciónUniversidad Industrial de Santander. Grupo de Epidemiología Clínica. Bucaramanga, Colombia.pt_BR
AfiliaciónUniversidad de Córdoba. Institute for Tropical Biology Research. Monteria, Córdoba, Colombia.pt_BR
AfiliaciónUniversidad Nacional Autónoma de Honduras. Instituto de Investigacion en Microbiologia. Tegucigalpa, Honduras.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónHarvard University. Harvard T. H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA. / Michigan State University. Department of Osteopathic Medical Specialties. East Lansing, Michegan, USA.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónThe Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, California, USA. / Scripps Translational Science Institute. La Jolla, California, USA / The Scripps Research Institute. Department of Integrative Structural and Computational Biology. La Jolla, California, USA.pt_BR
AfiliaciónFlorida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.pt_BR
AfiliaciónFlorida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil / Instituto DÓR de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónMassachusetts Institute of Technology. Institute for Medical Engineering and Science. Cambridge, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA .pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Harvard T.H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA.pt_BR
AfiliaciónBroad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA / Harvard University. Harvard T.H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA / Howard Hughes Medical Institute. Chevy Chase. Maryland, USA.pt_BR
Palavras clave en InglêsZika viruspt_BR
Palavras clave en InglêsEvolutionpt_BR
Palavras clave en InglêsAmericaspt_BR
e-ISSN1476-4687


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