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ZIKA VIRUS EVOLUTION AND SPREAD IN THE AMERICAS
Metsky, Hayden C. et al. | Date Issued: 2017
Author
Metsky, Hayden C.
Matranga, Christian B.
Wohl, Shirlee
Schaffner, Stephen F.
Freije, Catherine A.
Winnicki, Sarah M.
West, Kendra
Qu, James
Baniecki, Mary Lynn
Gladden-Young, Adrianne
Lin, Aaron E.
Tomkins-Tinch, Christopher H.
Ye, Simon H.
Park, Daniel J.
Luo, Cynthia Y.
Barnes, Kayla G.
Shah, Rickey R.
Chak, Bridget
Lima, Giselle Barbosa
Delatorre, Edson
Vieira, Yasmine R.
Paul, Lauren M.
Tan, Amanda L.
Barcellona, Carolyn M.
Porcelli, Mario C.
Vasquez, Chalmers
Cannons, Andrew C.
Cone, Marshall R.
Hogan, Kelly N.
Kopp, Edgar W.
Anzinger, Joshua J.
Garcia, Kimberly F.
Parham, Leda A.
Ramírez, Rosa M Gélvez
Montoya, Maria C. Miranda
Rojas, Diana P.
Brown, Catherine M.
Hennigan, Scott
Sabina, Brandon
Scotland, Sarah
Gangavarapu, Karthik
Grubaugh, Nathan D.
Oliveira, Glenn
Robles-Sikisaka, Refugio
Rambaut, Andrew
Gehrke, Lee
Smole, Sandra
Halloran, M. Elizabeth
Villar, Luis
Mattar, Salim
Lorenzana, Ivette
Cerbino Neto, José
Valim, Clarissa
Degrave, Wim
Bozza, Patrícia T.
Gnirke, Andreas
Andersen, Kristian G.
Isern, Sharon
Michael, Scott F.
Bozza, Fernando A.
Souza, Thiago Moreno L.
Bosch, Irene
Yozwiak, Nathan L.
MacInnis, Bronwyn L.
Sabeti, Pardis C.
Affilliation
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA / Harvard University. Harvard T.H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Massachusetts Institute of Technology. Harvard-MIT Health Sciences and Technology. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA / Harvard University. Harvard T.H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University Extension Schoo. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Florida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.
Florida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.
Florida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.
Miami-Dade County Mosquito Control. Miami, Florida, USA.
Miami-Dade County Mosquito Control. Miami, Florida, USA.
Florida Department of Health. Division of Disease Control and Health Protection. Bureau of Public Health Laboratories. Tampa, Florida, USA.
Florida Department of Health. Division of Disease Control and Health Protection. Bureau of Public Health Laboratories. Tampa, Florida, USA.
Florida Department of Health. Division of Disease Control and Health Protection. Bureau of Public Health Laboratories. Tampa, Florida, USA.
Florida Department of Health. Division of Disease Control and Health Protection. Bureau of Public Health Laboratories. Tampa, Florida, USA.
The University of the West Indies. Department of Microbiology. Mona, Kingston, Jamaica.
Universidad Nacional Autónoma de Honduras. Instituto de Investigacion en Microbiologia. Tegucigalpa, Honduras.
Universidad Nacional Autónoma de Honduras. Instituto de Investigacion en Microbiologia. Tegucigalpa, Honduras.
Universidad Industrial de Santander. Grupo de Epidemiología Clínica. Bucaramanga, Colombia.
Universidad Industrial de Santander. Grupo de Epidemiología Clínica. Bucaramanga, Colombia.
University of Florida. College of Public Health and Health Professions. Department of Epidemiology. Gainesville, Florida, USA.
Massachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.
Massachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.
Massachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.
Massachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.
The Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, California, USA..
The Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, California, USA..
Scripps Translational Science Institute. La Jolla, California, USA.
The Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, California, USA..
University of Edinburgh. Institute of Evolutionary Biology. Edinburgh EH9 3FL, UK / National Institutes of Health. Fogarty International Center. Bethesda, Maryland, USA.
Massachusetts Institute of Technology. Institute for Medical Engineering and Science. Cambridge, Massachusetts, USA / Harvard Medical School. Department of Microbiology and Immunobiology. Boston, Massachusetts, USA.
Massachusetts Department of Public Health. Jamaica Plain, Massachusetts, USA.
Fred Hutchinson Cancer Research Center, Seattle. Vaccine and Infectious Disease Division. Seattle, Washington, USA / University of Washington. Department of Biostatistics. Seattle, Washington, USA.
Universidad Industrial de Santander. Grupo de Epidemiología Clínica. Bucaramanga, Colombia.
Universidad de Córdoba. Institute for Tropical Biology Research. Monteria, Córdoba, Colombia.
Universidad Nacional Autónoma de Honduras. Instituto de Investigacion en Microbiologia. Tegucigalpa, Honduras.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Harvard University. Harvard T. H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA. / Michigan State University. Department of Osteopathic Medical Specialties. East Lansing, Michegan, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA.
The Scripps Research Institute. Department of Immunology and Microbial Science. La Jolla, California, USA. / Scripps Translational Science Institute. La Jolla, California, USA / The Scripps Research Institute. Department of Integrative Structural and Computational Biology. La Jolla, California, USA.
Florida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.
Florida Gulf Coast University. College of Arts and Sciences. Department of Biological Sciences. FortMyers, Florida, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil / Instituto DÓR de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.
Massachusetts Institute of Technology. Institute for Medical Engineering and Science. Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA .
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Harvard T.H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA.
Broad Institute of MIT and Harvard. Cambridge, Massachusetts, USA / Harvard University. Center for Systems Biology, Department of Organismic and Evolutionary Biology. Cambridge, Massachusetts. USA / Harvard University. Harvard T.H. Chan School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachusetts, USA / Howard Hughes Medical Institute. Chevy Chase. Maryland, USA.
Abstract
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.
Keywords in Portuguese
Zika virus
Evolução
Américas
 
Keywords
Zika virus
Evolution
Americas
 
Publisher
Nature Publishing Group
Citation
METSKY, Hayden C. et al. Zika virus evolution and spread in Americas. Nature, v. 546, n. 7658, p. 411-415, June 2017.
Previous version
https://www.arca.fiocruz.br/handle/icict/29542
DOI
10.1038/nature22402
ISSN
0028-0836
Notes
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