Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/1921
Title: Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
Authors: Santos, Milena Soares dos
Ribeiro, Guilherme de Sousa
Oliveira, Tainara Queiroz
Santos, Renan Cardoso Nery
Gouveia, Edilane Lins
Salgado, Kátia M
Takahashi, Daniele
Fontes, Cleuber
Campos, Leila Carvalho
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Reis, Joice Neves
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brazil.
Secretaria de Saúde do Estado da Bahia, Hospital Couto Maia, Salvador, Brazil.
Secretaria de Saúde do Estado da Bahia, Hospital Couto Maia, Salvador, Brazil.
Universidade Federal da Bahia, Faculdade de Farmácia, Salvador, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brazil.
Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, USA.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brazil.
Abstract: Over recent decades, a resurgence of invasive group A streptococcal (GAS) infections has been observed; GAS remains a rare cause of pyogenic meningitis. We report herein population-based findings of long-term surveillance for GAS meningitis in Salvador, Brazil, and estimate the overall burden of invasive GAS infections.From February 1996 to February 2007 we conducted active surveillance for GAS meningitis in the state reference hospital for infectious diseases in Salvador, Brazil. Data on clinical presentation, laboratory records, and outcome were collected through interviews and chart review. GAS isolates were evaluated for antimicrobial susceptibility and emm type.We identified 20 cases of GAS meningitis, which accounted for 0.9% of all culture-proven bacterial meningitis in the study period. The mean annual incidence of GAS meningitis was 0.03 cases per 100,000 population in metropolitan Salvador and peaked in children <1 year of age (0.67 cases per 100,000 population). Among 17 cases with clinical information available, 41% required intensive care unit support and 25% died. Tested isolates were susceptible to penicillin and exhibited large emm type diversity. Based on the incidence of GAS meningitis, we estimate that the annual incidence of GAS infection is 3 cases per 100,000 population in metropolitan Salvador.Although rare, GAS is a life-threatening cause of bacterial meningitis. Knowledge of the incidence and emm type variability of the disease is necessary for planning immunization strategies.
Keywords: Streptococcus pyogenes
Group A streptococcus
Meningitis
M typing
DeCS: Meningite Bacteriana
Infecções Estreptocócicas
Streptococcus agalactiae
Efeitos Psicossociais da Doença
Incidência
Agentes Antibacterianos
Issue Date: 2009
Citation: SANTOS, M. S. et al. Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance. International Journal of Infectious Diseases, v.13, n.4, p.456-461, jul. 2009.
DOI: 10.1016/j.ijid.2008.09.006
ISSN: 1201-9712
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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