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GENETIC DIVERSITY OF NS5A PROTEIN FROM HEPATITIS C VIRUS GENOTYPE 3A AND ITS RELATIONSHIP TO THERAPY RESPONSE
Bittar, Cíntia et al. | Date Issued: 2010
Author
Bittar, Cíntia
Jardim, Ana Carolina Gomes
Yamasaki, Lilian Hiromi Tomonari Yamasaki
Queiróz, Artur Trancoso Lopo de
Carareto, Claudia Maria Aparecida
Pinho, João Renato Rebello
Mello, Isabel Maria Vicente Guedes de Carvalho
Rahal, Paula
Affilliation
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo University. São Paulo, SP, Brazil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo University. Faculty of Medicine. Institute of Tropical Medicine. Department of Gastroenterology. Laboratory of Hepatology and Gastroenterology. São Paulo, SP, Brazil / Albert Einstein Israeli Hospital. Department of Clinical Pathology. São Paulo, SP, Brazil
Butantan Institute. Viral Immunology Laboratory. Butantã, São Paulo, SP, Brazil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
Abstract
The quasispecies nature of HCV may have important implications for viral persistence, pathogenicity and resistance to antiviral agents. The variability of one of the viral proteins, NS5A, is believed to be related to the response to IFN therapy, the standard treatment for infection. In this study we analyzed the quasispecies composition of NS5A protein in patients infected with HCV genotype 3a, before IFN therapy.
Keywords in Portuguese
Hepatite C Crônica
Genótipo
Doenças virais
RNA Viral
Variação genética
Hepacivirus
Humanos
 
Keywords
Hepatitis C Chronic
Genotype
Antiviral Agents
RNA Viral
Genetic Variation
Hepacivirus
Humans
 
DeCS
Hepatite C Crônica
Genótipo
Doenças virais
RNA Viral
Variação genética
Hepacivirus
Humanos
 
Publisher
BioMed Central
Citation
BITTAR, C. et al. Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response. BMC Infectious Diseases, v. 10, p. 36, 2010
DOI
10.1186/1471-2334-10-36
ISSN
1471-2334
Notes
Artur Trancoso Lopo de Queiroz “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.