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GENETIC DIVERSITY OF NS5A PROTEIN FROM HEPATITIS C VIRUS GENOTYPE 3A AND ITS RELATIONSHIP TO THERAPY RESPONSE
Genótipo
Doenças virais
RNA Viral
Variação genética
Hepacivirus
Humanos
Genotype
Antiviral Agents
RNA Viral
Genetic Variation
Hepacivirus
Humans
Author
Affilliation
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo University. São Paulo, SP, Brazil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo University. Faculty of Medicine. Institute of Tropical Medicine. Department of Gastroenterology. Laboratory of Hepatology and Gastroenterology. São Paulo, SP, Brazil / Albert Einstein Israeli Hospital. Department of Clinical Pathology. São Paulo, SP, Brazil
Butantan Institute. Viral Immunology Laboratory. Butantã, São Paulo, SP, Brazil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo University. São Paulo, SP, Brazil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
São Paulo University. Faculty of Medicine. Institute of Tropical Medicine. Department of Gastroenterology. Laboratory of Hepatology and Gastroenterology. São Paulo, SP, Brazil / Albert Einstein Israeli Hospital. Department of Clinical Pathology. São Paulo, SP, Brazil
Butantan Institute. Viral Immunology Laboratory. Butantã, São Paulo, SP, Brazil
São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, Brasil
Abstract
The quasispecies nature of HCV may have important implications for viral persistence, pathogenicity and resistance to antiviral agents. The variability of one of the viral proteins, NS5A, is believed to be related to the response to IFN therapy, the standard treatment for infection. In this study we analyzed the quasispecies composition of NS5A protein in patients infected with HCV genotype 3a, before IFN therapy.
Keywords in Portuguese
Hepatite C CrônicaGenótipo
Doenças virais
RNA Viral
Variação genética
Hepacivirus
Humanos
Keywords
Hepatitis C ChronicGenotype
Antiviral Agents
RNA Viral
Genetic Variation
Hepacivirus
Humans
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