Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/19343
PREVALENCE OF THE MUTATION C677 ® T IN THE METHYLENE TETRAHYDROFOLATE REDUCTASE GENE AMONG DISTINCT ETHNIC GROUPS IN BRAZIL
Homocisteína
Ácido fólico
Doença arterial
Trombose venosa
Homocysteine
Folic acid
Arterial disease
Venous thrombosis
Author
Affilliation
State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil
State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil
Federal University of Bahia. Salvador, BA, Brazil
State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil
Evandro Chagas Institute. Belém, PA, Brazil
Evandro Chagas Institute. Belém, PA, Brazil
State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil
State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil
State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil
Federal University of Bahia. Salvador, BA, Brazil
State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil
Evandro Chagas Institute. Belém, PA, Brazil
Evandro Chagas Institute. Belém, PA, Brazil
State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil
State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil
Abstract
Vascular disease is a serious public health
problem in the industrialized world, and is a
frequent cause of death among the adult
population of Brazil. Mild hyperhomocysteinemia
has been identified as a risk factor
for arterial disease, venous thrombosis, and
neural tube defects. Individuals homozygous
for the thermolabile variant of methylenetetrahydrofolate
reductase (MTHFR-T)
are found in 5–15% of the general population
and have significantly elevated plasma homocysteine
levels which represent one of
the genetic risk factors for vascular diseases.
We have analyzed the prevalence of
individuals homozygous for the MTHFR-T
in 327 subjects representing the three distinct
ethnic groups in Brazil. The prevalence
of homozygotes for the mutated allele
MTHFR-T was high among persons of Caucasian
descent (10%) and considerably
lower among Black (1.45%) and Indians persons
populations (1.2%). These data suggest
that screening for the MTHFR-T allele
should help in identifying individuals with
a high risk of vascular disease among populations
with a heterogeneous background
Keywords in Portuguese
Metilenetetra-hidrofolato redutaseHomocisteína
Ácido fólico
Doença arterial
Trombose venosa
Keywords
Methylenetetrahydrofolate reductase geneHomocysteine
Folic acid
Arterial disease
Venous thrombosis
Share