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IL-33 SIGNALING IS ESSENTIAL TO ATTENUATE VIRAL-INDUCED ENCEPHALITIS DEVELOPMENT BY DOWNREGULATING INOS EXPRESSION IN THE CENTRAL NERVOUS SYSTEM
Franca, Rafael F. O. et al. | Date Issued: 2016
Author
Franca, Rafael F. O.
Costa, Renata S.
Silva, Jaqueline R.
Peres, Raphael S.
Mendonça, Leila R.
Colón, David F.
Alves-Filho, José Carlos
Cunha, Fernando Q.
Affilliation
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.
University of São Paulo. Program of Basic and Applied Immunology. Ribeirão Preto, SP, Brazil.
University of São Paulo. Program of Basic and Applied Immunology. Ribeirão Preto, SP, Brazil.
University of São Paulo. Program of Basic and Applied Immunology. Ribeirão Preto, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.
University of São Paulo. Program of Basic and Applied Immunology. Ribeirão Preto, SP, Brazil.
University of São Paulo. Ribeirão Preto School of Medicine. Department of Pharmacology. Ribeirão Preto, SP, Brazil.
University of São Paulo. Ribeirão Preto School of Medicine. Department of Pharmacology. Ribeirão Preto, SP, Brazil.
Abstract
Viral encephalitis is a common cause of lethal infections in humans, and several different viruses are documented to be responsible. Rocio virus is a flavivirus that causes a severe lethal encephalitis syndrome in humans and also mice, providing an interesting model to study the CNS compartmentalized immune response. Interleukin 33 (IL-33), a member of the IL-1 family, is an immunomodulatory cytokine that is highly expressed in the CNS. However, the role of IL-33 on viral encephalitis remains unclear. Therefore, we aimed to explore how the IL-33/ST2 axis regulates the local immune response during Rocio virus infection.
Keywords in Portuguese
Interleucina 33
Receptor ST2
Encefalite viral experimental
Óxido nítrico
Flavivirus
 
Keywords
Interleukin 33
ST2 receptor
Experimental viral encephalitis
Nitric oxide
Flavivirus
 
DeCS
Sistema Nervoso Central / imunologia
Sistema Nervoso Central / patologia
Sistema Nervoso Central / virologia
Encefalite Viral / patologia
Interleucina-33 / metabolismo
Óxido Nítrico Sintase Tipo II / metabolismo
 
Citation
FRANCA, R. F. O. et al. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. Journal of Neuroinflammation, v. 13, n. 1, dez. 2016.
DOI
10.1186/s12974-016-0628-1
ISSN
1742-2094