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AEROBIC EXERCISE TRAINING INDUCES SUPERIOR CARDIOPROTECTION FOLLOWING MYOCARDIAL ISCHEMIA REPERFUSION INJURY THAN A SINGLE AEROBIC EXERCISE SESSION IN RATS
Autor(es)
Afiliação
Universidade do Estadol do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Universidade do Estadol do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Universidade do Estadol do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Resumo em Inglês
Abstract — Aim: To compare the amount of cardioprotection induced by a single exercise session with those achieved
after an 8-week aerobic exercise training following ischemia reperfusion injury in rats. Methods: Twenty-five male
Wistar rats (250-300g) were assigned into a group submitted to physical training (TR; n=12) or a single maximal
exercise session (EXE; n=13). Following sedentarism or physical training (8 weeks, 5 sessions/wk, 1h/session at 70%
of maximal speed) both groups performed a maximal exercise test. Then, groups were submitted to ischemia reperfusion
injury (30 min/1h) through an isolated heart protocol, in which left ventricle developed pressure was measured.
Results: The TR group presented greater maximal oxygen consumption compared to the EXE group (77.25±20.41 vs
41.32±25.86 ml/Kg/min; P=0.003). Regarding left ventricle developed pressure, no differences were detected between
groups at baseline (TR: 89.78±24.40 vs EXE: 81.37±31.84 mmHg; P=0.48). However, after reperfusion, the TR group
presented superior intraventricular pressure than EXE group (37.94±18.34 vs 21.59±13.67 mmHg; P=0.03). Conclusion:
Eight-week aerobic training induced greater cardioprotection against ischemia reperfusion injury in rats compared to a
single exercise session, due to an increased cardiac function. This suggests that exercise-induced cardioprotection is a
multifactorial process that may involve different mediators according to the exercise duration.
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