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ACCURACY OF CHIMERIC PROTEINS IN THE SEROLOGICAL DIAGNOSIS OF CHRONIC CHAGAS DISEASE - A PHASE II STUDY
Santos, Fred Luciano Neves et al. | Date Issued: 2017
Author
Santos, Fred Luciano Neves
Celedon, Paola Alejandra Fiorani
Zanchin, Nilson Ivo Tonin
Souza, Wayner Vieira de
Silva, Edimilson Domingos da
Foti, Leonardo
Krieger, Marco Aurélio
Gomes, Yara de Miranda
Affilliation
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil.
Molecular Biology Institute of Paraná. Curitiba, PR, Brazil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brazil.
Molecular Biology Institute of Paraná. Curitiba, PR, Brazil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil / Molecular Biology Institute of Paraná. Curitiba, PR, Brazil / Fundação Oswaldo Cruz. Instituto Carlos Chagas Institute. Curitiba, PR, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil.
Abstract
The performance of current serologic tests for diagnosing chronic Chagas disease (CD) is highly variable. The search for new diagnostic markers has been a constant challenge for improving accuracy and reducing the number of inconclusive results.
Keywords in Portuguese
Doença de Chagas
Diagnóstico
Testes Sorológicos
 
DeCS
Anticorpos, protozoários / sangue
Antígenos, protozoários / imunologia
Doença de Chagas / diagnóstico
Proteínas Recombinantes / imunologia
Trypanosoma cruzi / imunologia
 
Citation
SANTOS, Fred Luciano Neves et al. Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease – a Phase II study. PLOS Neglected Tropical Diseases, v. 11, n. 3, p. 1-20, Mar. 2017.
DOI
10.1371/journal.pntd.0005433
ISSN
1935-2735