Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/19513
Title: Interferon-gamma levels during the course of Trypanosoma cruzi infection of Calomys callosu$ (Rodentia-Cricetidae) and Swiss mice
Authors: Borges, Monamaris Marques
Vassao, Ruth
Andrade, Sonia Gumes
Pereira, Carlos Augusto
Kloetzel, Judith K
Affilliation: Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil
Instituto Butantan. Laboratório de Imanunologia Viral. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Instituto Butantan. Laboratório de Imanunologia Viral. São Paulo, SP, Brasil
Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil
Abstract: Serum levels of interferon-gamma (IFN-y) were evaluated in Calomys callosus and Swiss mice during the course of infection by four strains of Trypanosoma cruzi. All strains stimulated the production of this interleukine; however, the timing of its onset and permanence varied among strains and between the two animal models. When chronically infected animals with no detectable serum IFN-y were challenged with the homologous strain, they produced quantities comparable with those obtained during the acute phase of infection. In C. callosus there was a correlation between H202 liberation by peritoneal macrophages and serum IFN-y levels, whereas no such correlation was found in mice. C. callosus had a higher capacity to heal histopathological lesions, whereas lesions in mice were progressive, The results obtained suggest that C. callosus develops welladapted immune mechanisms that may be important for its role as a reservoir of T. cruzi.
Keywords: Trypanosoma cruzi
Rodentia
Animals
Infection
Mice
Interferon gamma
keywords: Trypanosoma cruzi
Rodentia
Animais
Infecção
Ratos
Interferon gama
Issue Date: 1995
Publisher: Springer Verlag
Citation: BORGES, M. M. et al. Interferon-gamma levels during the course of Trypanosoma cruzi infection of Calomys callosu$ (Rodentia-Cricetidae) and Swiss mice. Parasitology Research, v. 81, p. 498-504, 1995.
ISSN: 0932-0113
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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