Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/19535
Title: New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni
Other Titles: Novo índice biológico para o diagnóstico da fibrose hepática na Esquistossomose mansoni
Authors: Barreto, Ana Virgínia Matos Sá
Alecrim, Vinícius Martins
Medeiros, Tibério Batista de
Domingues, Ana Lúcia Coutinho
Lopes, Edmundo Pessoa
Martins, João Roberto Maciel
Nader, Helena Bonciani
Diniz, George Tadeu Nunes
Montenegro, Silvia Maria Lucena
Morais, Clarice Neuenschwander Lins de
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
Abstract: Background – Periportal fibrosis is the major pathological consequence of the Schistosoma mansoni infection. Objective – To evaluate the accuracy of serum markers and to construct an index to assess fibrosis. Methods – Patients (n=116) with schistosomiasis were evaluated by ultrasound scan and measurements of serum levels of aminotransferases, γ-glutamyl transferase, alkaline phosphatase, hyaluronic acid, cytokines and platelets. Ultrasound images were used to evaluate the fibrosis using Niamey’s classification and identified 19 patients without periportal fibrosis (patterns A and B), 48 with mild to moderate fibrosis (C and D) and 49 with advanced fibrosis (E and F). Results – Using multivariate analysis, a model was created, which involved alkaline phosphatase and platelets and could separate patients with different patterns of fibrosis. This index showed a better performance in separating patients without fibrosis from with advanced periportal fibrosis. The biological index showed an area under the ROC curve of 1.000. Using values below the lowest or above the highest cut-off point, the presence or absence of advanced fibrosis could be predicted in all patients. Conclusion – The index constructed can be used to separate patients with different patterns of periportal fibrosis, specially to predict advanced fibrosis in schistosomiasis patients.
Keywords: Adolescent
Adult
Aged
Alkaline Phosphatase
Biomarkers
Blood Platelets
Cytokines
Female
gamma-Glutamyltransferase
Humans
Hyaluronic Acid
Liver Cirrhosis
Male
Middle Aged
Predictive Value of Tests
Schistosomiasis mansoni
Sensitivity and Specificity
Severity of Illness Index
Transaminases
Young Adult
keywords: Esquistossomose mansoni
Fibrose
Curva ROC
DeCS: Adolescente
Adulto
Idoso
Fosfatase Alcalina
Biomarcadores
Plaquetas
Citocinas
Feminino
Humanos
Ácido Hialurônico
Ácido Hialurônico
Masculino
Meia-Idade
Valor Preditivo dos Testes
Esquistossomose mansoni
Sensibilidade e Especificidade
Índice de Gravidade de Doença
Transaminases
Adulto Jovem
gama-Glutamiltransferase
Issue Date: 2017
Citation: BARRETO, A. V. M. S. et al. New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni. Arquivos De Gastroenterologia, v. 54, n. 1, p. 51–56, mar. 2017. DOI 10.1590/S0004-2803.2017v54n1-10.
DOI: 10.1590/S0004-2803.2017v54n1-10
ISSN: 1678-4219
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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