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2030-01-01
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HEPATITIS C VIRUS AND HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE 1 CO-INFECTION: IMPACT ON LIVER DISEASE, VIROLOGICAL MARKERS, AND NEUROLOGICAL OUTCOMES
Espíndola, Otávio M. et al. | Date Issued: 2017
Author
Espíndola, Otávio M.
Vizzoni, Alexandre G.
Lampe, Elisabeth
Serpa, Maria José Andrada
Araújo, Abelardo Q. C.
Leite, Ana Claudia C.
Affilliation
Fundação Oswaldo Cruz. Instituto Nacional Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ. Brasil.
Abstract
Human T-cell lymphotropic virus type 1 (HTLV-1) infection is associated with neurological abnormalities, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and peripheral neuropathy (PN). Hepatitis C virus (HCV) infection is the leading cause of chronic liver disease worldwide, and causes PN in approximately 9% of patients. Because the interplay between these potentially neuropathogenic viruses in the same individual is still poorly understood, the clinical and laboratory outcomes of co-infected patients were evaluated and compared with those of controls.
Keywords in Portuguese
Hepacivirus
Doenças do Sistema Nervoso Periférico
Vírus 1 Linfotrópico T Humano
Envolvimento hepático
 
Keywords
HCV
HTLV-1
Co-infection
Hepatic involvement
Peripheral neuropathy
 
Publisher
Elsevier
Citation
ESPÍNDOLA, Otávio M. et al. Hepatitis C virus and human T-cell lymphotropic virus type 1 co-infection: impact on liver disease, virological markers, and neurological outcomes. International Journal of Infectious Diseases, v.57, p.116–122, 2017.
DOI
10.1016/j.ijid.2017.01.037
ISSN
1201-9712