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THE ANTI-HYPERALGESIC AND ANTI-INFLAMMATORY PROFILES OF P-CYMENE: EVIDENCE FOR THE INVOLVEMENT OF OPIOID SYSTEM AND CYTOKINES
Santana, Michele Fraga de et al. | Date Issued: 2015
Author
Santana, Michele Fraga de
Guimarães, Adriana Gibara
Chaves, Danielle Oliveira
Silva, Juliane Cabral
Bonjardim, Leonardo Rigoldi
Lucca Júnior, Waldecy de
Ferro, Jamylle Nunes de Souza
Barreto, Emiliano de Oliveira
Santos, Flávia Evangelista dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Quintans, Jullyana de Souza Siqueira
Quintans Júnior, Lucindo José
Affilliation
Federal University of Sergipe. Department of Physiology. São Cristovão, SE, Brazil
Federal University of Sergipe. Department of Health Education. São Cristovão, SE, Brazil
Federal University of Sergipe. Department of Physiology. São Cristovão, SE, Brazil
Federal University of Sergipe. Department of Physiology. São Cristovão, SE, Brazil
University of São Paulo. Department of Biological Sciences. Bauru, SP, Brazil
Federal University of Sergipe. Department of Morphology. São Cristovão, SE, Brazil
Federal University of Alagoas. Cell Biology Laboratory. Maceió, AL, Brazil
Federal University of Alagoas. Cell Biology Laboratory. Maceió, AL, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Department of Pharmacy. Salvador, BA, Brazil
Federal University of Sergipe. Department of Physiology. São Cristovão, SE, Brazil
Federal University of Sergipe. Department of Physiology. São Cristovão, SE, Brazil
Abstract
Pain corresponds to the most frequent reason for visits to physicians, and its control by conventional drugs is accompanied by several side effects, making treatment difficult. For this reason, new chemical entities derived from natural products still hold great promise for the future of drug discovery to pain treatment.
Keywords in Portuguese
Monoterpenos
Opioides
Dor
TNF-a
 
Keywords
Monoterpene
Opioid system
Pain
TNF-a
 
Publisher
Taylor & Francis: STM, Behavioural Science and Public Health Titles
Citation
SANTANA, M. F. et al. The anti-hyperalgesic and anti-inflammatory profiles of p-cymene: Evidence for the involvement of opioid system and cytokines. Pharmaceutical Biology, v. 53, n. 11, p. 1583–1590, 2015.
DOI
10.3109/13880209.2014.993040
ISSN
1388-0209