Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20055
Title: MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
Authors: Fernandes, Juliana Dumet
Hsieh, Ricardo
Freitas, Luiz Antonio Rodrigues de
Brandao, Miguel Angelo Rodrigues
Lourenço, Silvia Vanessa
Sangueza, Martin
Nico, Marcello Menta Simonsen
Affilliation: Federal University of Bahia. Medical School. Department of Dermatology. Salvador, BA, Brazil
University of São Paulo. Dental School. Department of General Pathology. São Paulo, SP, Brazil
Federal University of Bahia. Medical School. Department of Pathology. Salvador, BA, Brazil
AMO. Oncological Clinic Care. Salvador, BA, Brazil
University of São Paulo. Dental School. Department of General Pathology. São Paulo, SP, Brazil / University of São Paulo. Medical School. Department of Dermatology. São Paulo, SP, Brazil
Hospital Obrero. Department of Surgical Pathology. La Paz, Bolivia
University of São Paulo. Medical School. Department of Dermatology. São Paulo, SP, Brazil
Abstract: The etiology and pathogenesis of lentiginous acral melanomas are poorly understood. Recent studies have postulated that DNA repair mechanisms and cell growth pathways are involved in the development of melanoma, particularly changes in the MAPK pathways (RAS, BRAF, MEK 1/2, and ERK 1/2). The aim of this study is to assess the status of the MAP kinase pathways in the pathogenesis of acral melanomas. The authors examined the components of the RAS-RAF-MEK-ERK cascades by immunohistochemistry in a series of 16 primary acral melanomas by tissue microarray. The expression of MAP kinase cascade proteins changed in most cases. The authors observed that 57.14% of cases were BRAF positive and that 61.53%, 71.42%, and 71.42% of cases were positive for MEK2, ERK1, and ERK2, respectively; RAS was not expressed in 92.31%, and all cases were negative for MEK1. The absence of RAS and positivity for MEK2, ERK1, and ERK2 were most seen in invasive cases with high thickness. These aspects of the MAPK pathway require further examination in acral melanomas between different populations. Nevertheless, the results highlight significant alterations in the MAP kinase cascades that are related to histological indicators of prognosis in primary acral melanomas.
Keywords: Melanoma
Acral
Skin cancer
MAPK kinase
keywords: Melanoma
Acral
Câncer de pele
MAPK quinases
Issue Date: 2015
Publisher: Lippincott, Williams & Wilkins
Citation: FERNANDES, J. D. et al. MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. American Journal of Dermatopathology, v. 37, n. 12, p. 892–897, 2015.
Description: Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
DOI: 10.1097/DAD.0000000000000317
ISSN: 0193-1091
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Fernandes JD MAP kinase pathways.pdf400.48 kBAdobe PDFView/Open



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.