Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20090
Title: Interference of flavonoids and carotenoids on the antimicrobial activity of some drugs against clinical isolates of Pseudomonas aeruginosa
Authors: Dos Santos, R.
Freire, G. Pimenta
Figueiredo, Flávio Júnior Barbosa
Souza, M.V. Dias
Affilliation: Universidade Federal de Minas. Faculdade de Farmácia. Belo Horizonte, MG, Brazil
Universidade Federal de Minas. Faculdade de Farmácia. Belo Horizonte, MG, Brazil
Faculdades Santo Agostinho. Coordenação de Ensino, Pesquisa e Extensão. Montes Claros, MG, Brasil/Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil
Universidade Federal de Minas. Faculdade de Ciências de Biológicas. Belo Horizonte, MG, Brazil
Abstract: The use of phytonutrients in pharmaceutical dosage forms aiming a healthier lifestyle has increased worldwide, and in spite of being generally an useful healthcare measure, this is not free of risks when concomitant medication use is considered. The combined use of phytonutrients and medication remains poorly investigated, and represents a serious problem in drug therapy, given that side effects due to drug-nutrient interactions are poorly predictable. In this study, three drugs were tested in combination to lycopene β-carotene (carotenoids), diosmin and curcumin (flavonoids) against clinical isolates of P. aeruginosa. Strains identity was confirmed by automated methods and the interference of phytomolecules on the pharmacological activity of the chosen drugs was assessed in vitro using antimicrobial disks. Here we show that lycopene, β-carotene, diosmin and curcumin can act synergistically when combined to antimicrobial drugs against clinical isolates of P. aeruginosa. In vivo studies are necessary for assessing the biological effects of these interactions considering clinical contexts.
Keywords: Pseudomonas aeruginosa
keywords: Pseudomonas aeruginosa
Issue Date: 2016
Publisher: Universiti Putra Malaysia
Citation: DOS SANTOS, R. Interference of flavonoids and carotenoids on the antimicrobial activity of some drugs against clinical isolates of Pseudomonas aeruginosa. International Food Research Journal, v. 23, n. 3, p. 1268-1273, 2016
ISSN: 1985-4668
Copyright: restricted access
Appears in Collections:IRR - Artigos de Periódicos

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