Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20111
Title: Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.
Authors: Iani, Felipe Campos de Melo
Caldas, Sérgio
Duarte, Myrian Morato
Cury, Ana Luisa Furtado
Cecílio, Alzira Batista
Costa, Pedro Augusto Carvalho
Antonelli, Lis Ribeiro do Valle
Gollob, Kenneth J.
Affilliation: Fundação Ezequiel Dias. Instituto Octávio Magalhães. Divisão de Epidemiologia e Controle de Doenças. Belo Horizonte, MG, Brazil/Hospital Santa Casa. Instituto de Ensino e Pesquisa. Programa de Pós-graduação em Medicina e Biomedicina. Belo Horizonte, MG, Brazil.
Fundação Ezequiel Dias. Diretoria de Pesquisa e Desenvolvimento. Divisão de Plataformas Tecnológicas. Belo Horizonte, MG, Brazil.
Fundação Ezequiel Dias. Instituto Octávio Magalhães. Divisão de Epidemiologia e Controle de Doenças. Belo Horizonte, MG, Brazil
Fundação Ezequiel Dias. Instituto Octávio Magalhães. Divisão de Epidemiologia e Controle de Doenças. Belo Horizonte, MG, Brazil
Fundação Ezequiel Dias. Diretoria de Pesquisa e Desenvolvimento. Divisão de Plataformas Tecnológicas. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Hospital Santa Casa. Instituto de Ensino e Pesquisa. Programa de Pós-graduação em Medicina e Biomedicina. Belo Horizonte, MG, Brazil/Institutos Nacionais de Ciências e Tecnologia-Doenças Tropicais. Belo Horizonte, MG, Brazil
Abstract: Dengue is responsible for a wide range of clinical manifestations, ranging from asymptomatic infections to severe cases. The alteration of cytokine levels correlated with clinical characteristics can help determine prognostic markers of the disease and the identification of targets for immunotherapy. We measured the viral load, serotype, and cytokine levels of 212 serum samples from patients with acute dengue infection during days 1–4 after the onset of symptoms. The patients were classified as either with hemorrhagic manifestations (HM) or with no hemorrhagic manifestations (NHM). The cytokines interleukin-6 (IL-6), IL-8, and IL-10 were increased (P < 0.05) in the dengue virus+ group, compared with the control group. A higher viral load (P < 0.05) and IL-6 was detected in the HM group compared with the NHM group. Interestingly, the NHM group demonstrated a significant positive correlation between inflammatory (IL-6 and 8) and anti-inflammatory (IL-10) cytokines, whereas the HM group did not. These findings suggest that a disturbance in the balance of inflammatory cytokines IL-6 and IL-8 with the anti-inflammatory cytokine, IL-10, combined with the high levels of IL-6 and viral load, characterize possible mechanisms related to the formation of HM.
Keywords: Dengue
keywords: Dengue
Issue Date: 2016
Publisher: American Society of Tropical Medicine and Hygiene
Citation: IANI, Felipe Campos de Melo et al. Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8. Am J Trop Med Hyg., v. 95, n. 1, p. 193–200, 2016.
DOI: 10.4269/ajtmh.15-0537
ISSN: 0002-9637
Copyright: open access
Appears in Collections:IRR - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Iani_Felipe_Dengue Patients_IRR_2016.pdf5.94 MBAdobe PDF    Request a copy


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.