Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20147
Title: Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis
Authors: Rocha, Paulo Novis
Almeida, Roque Pacheco de
Bacellar, Olívia
Jesus, Amélia Maria Ribeiro de
Correia Filho, Dalmo
Cruz Filho, Álvaro
Barral, Aldina Maria Prado
Coffman, Robert L
Carvalho Filho, Edgar Marcelino
Affilliation: Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal de Uberaba. Uberaba, MG, Brasil
Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
DNAX Research Institute. Palo Alto, California
Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Abstract: This study examined the T cell responses in the early phase of Leishmania braziliensis infection. Cytokine profiles, lymphoproliferative responses, and skin test results in 25 patients with early cutaneous leishmaniasis (ECL; illness duration !60 days) were compared with those in persons with late cutaneous leishmaniasis (LCL; illness duration 12 months). Absent or low lymphoproliferative responses were observed in 8 (32%) of 25 patients and an absence of interferon (IFN)–g production in 9 (41%) of 22 patients prior to therapy. IFN-g production in ECL (mean 5 SD) was lower than in LCL (2935346 vs. 7475377 pg/mL, respectively; P ! .01). In contrast, interleukin (IL)–10 production in ECL (mean 5 SD) was higher than in LCL (246556 vs. 50541 pg/mL, respectively;P ! .01) .Restoration of lymphoproliferative responses and IFN-g production was achieved when monoclonal antibody to IL-10 or IL-12 was added to the cultures. These results show that T cell responses during early-phase infection are down-regulated by IL-10 and may facilitate parasite multiplication.
Keywords: Leishmania braziliensis
Leishmaniasis, Cutaneous
Lymphoproliferative disorders
Humans
Cytokine
keywords: Leishmania braziliensis
Leishmaniose Cutânea
Transtornos linfoproliferativos
Humanos
Citocinas
Issue Date: 1999
Publisher: Oxfor University Press
Citation: ROCHA, P. N. et al. Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis. The Journal of Infectious Diseases, v. 180, p. 1731–1734, 1999.
Description: Barral, Aldina Maria Prado “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
ISSN: 0022-1899
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Rocha P. Down regulation of Th1.....pdf91.2 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.