Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20606
Title: Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV
Authors: Inocencio, Lilian A.
Pereira, Anderson A.
Sucupira, Maria Cecilia A.
Fernandez, José Carlos C.
Jorge, Célia P.
Fink, Helena T.
Diaz, Ricardo S.
Becker, Irina M.
Suffert, .Theodoro A.
Arruda, Monica B.
Macedo, Olinda
Simão, Mariangela B. G.
Tanuri, Amilcar
Affilliation: Ministério da Saúde. Programa Brasileiro DST/AIDS. Brasília, DF, Brasil.
Ministério da Saúde. Programa Brasileiro DST/AIDS. Brasília, DF, Brasil.
Universidade Federal de São Paulo. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ. Brasil.
Universidade Federal da Bahia. Laboratório de Biologia Molecular. Salvador, BA, Brasil
Ministério da Saúde. Prograna Brasileiro DST/AIDS. Brasília, DF, Brasil.
Laboratório de Saúde Pública. Brasília, DF, Brasil
Universidade Federal de São Paulo. São Paulo, SP, Brasil.
Laboratório de Saúde Pública. Porto Alegre, RS, Brasil.
Prefeitura de Porto Alegre. Centro de Saúde do Porto. Porto Alegre, RS, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biociências. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil
Universidade Federal do Rio de Janeiro. Instituto de Biociências. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil
Ministério da Saúde. Programa Brasileiro DST/AIDS. Brasília, DF, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biociências. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil
Abstract: Use of antiretrovirals is widespread in Brazil, where more than 200,000 individuals are under treatment. Although general prevalence of primary antiretroviral resistance in Brazil is low, systematic sampling in large metropolitan areas has not being performed.The HIV Threshold Survey methodology (HIV-THS, WHO) was utilized, targeting Brazil's four major regions and selecting the six most populated state capitals: Sao Paulo, Rio de Janeiro, Salvador, Porto Alegre, Brasilia and Belem. We were able to sequence samples from 210 individuals with recent HIV diagnosis, 17 of them (8.1%) carrying HIV isolates with primary antiretroviral resistance mutations. Five, nine and four isolates showed mutations related to resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs), respectively. Using HIV-THS, we could find an intermediate level of transmitted resistance (5% to 15%) in Belem/Brasilia, Sao Paulo and Rio de Janeiro. Lower level of transmitted resistance (<5%) were observed in the other areas. Despite the extensive antiretroviral exposure and high rates of virologic antiretroviral failure in Brazil, the general prevalence of primary resistance is still low. However, an intermediate level of primary resistance was found in the four major Brazilian cities, confirming the critical need to start larger sampling surveys to better define the risk factors associated with transmission of resistant HIV.
Keywords: AIDS
Antiretroviral Therapy
Drugs
Diagnosis
keywords: AIDS
Antiretrovirais
Diagnóstico
Tratamento
Medicamentos
Issue Date: 2009
Publisher: BioMed Central
Citation: INOCENCIO. Lilian A. et al. Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV. Journal of the International AIDS Survey, v.12, n.20, 6p, Sept. 2009.
DOI: 10.1186/1758-2652-12-20
ISSN: 1758-2652
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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