Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20775
Title: Sand-fly saliva-leishmania-man: the trigger trio
Authors: Oliveira, Luiz Fabiano Borges
Carvalho, Augusto Marcelino Pedreira de
Oliveira, Camila Indiani de
Affilliation: National Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Malaria and Vector Research. Vector Biology Section. Rockville, MD, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. INCT. Salvador, BA, Brazil
Abstract: Leishmaniases are worldwide diseases transmitted to the vertebrate host by the bite of an infected sand-fly. Sand-fly biting and parasite inoculation are accompanied by the injection of salivary molecules, whose immunomodulatory properties are actively being studied. This mini review focuses on how the interactions between sand-fly saliva and the immune system may shape the outcome of infection, given its immunomodulatory properties, in experimental models and in the endemic area. Additionally, we approach the recent contributions regarding the identification of individual salivary components and how these are currently being considered as additional components of a vaccine against leishmaniasis.
Keywords: Sand-fly
Saliva
Leishmania
Vaccine
Leishmaniasis
keywords: Mosca de areia
Saliva
Leishmania
Vacina
Leishmaniose
Issue Date: 2013
Publisher: Frontiers Media
Citation: OLIVEIRA, L. F. B.; CARVALHO, A. M. P.; OLIVEIRA, C. I. Sand-fly saliva-leishmania-man: the trigger trio. Frontiers in Immunology, v. 4, article 375, 2013.
DOI: 10.3389/fimmu.2013.00375
ISSN: 1664-3224
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Oliveira, FO Sand-Fly salive... .pdf558.58 kBAdobe PDFView/Open



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.