Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20779
Title: The citrus flavanone naringenin impairs dengue virus replication in human cells
Authors: Frabasile, Sandra
Koishi, Andrea Cristine
Kuczera, Diogo
Silveira, Guilherme Ferreira
Verri Jr, Waldiceu Aparecido
Santos, Claudia Nunes Duarte dos
Bordignon, Juliano
Affilliation: Facultad de Ciencias, Universidad de La República. Sección Virologia. Montevideo, Uruguay. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Londrina, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Abstract: Dengue is one of the most significant health problems in tropical and sub-tropical regions throughout the world. Nearly 390 million cases are reported each year. Although a vaccine was recently approved in certain countries, an anti-dengue virus drug is still needed. Fruits and vegetables may be sources of compounds with medicinal properties, such as flavonoids. This study demonstrates the anti-dengue virus activity of the citrus flavanone naringenin, a class of flavonoid. Naringenin prevented infection with four dengue virus serotypes in Huh7.5 cells. Additionally, experiments employing subgenomic RepDV-1 and RepDV-3 replicon systems confirmed the ability of naringenin to inhibit dengue virus replication. Antiviral activity was observed even when naringenin was used to treat Huh7.5 cells 24 h after dengue virus exposure. Finally, naringenin anti-dengue virus activity was demonstrated in primary human monocytes infected with dengue virus sertoype-4, supporting the potential use of naringenin to control dengue virus replication. In conclusion, naringenin is a suitable candidate molecule for the development of specific dengue virus treatments.
Keywords: Antiviral Agents
Flavonoids
Flavanones
Dengue Virus
Keywords in spanish: Antivirales
Flavonoides
Flavanonas
Virus del Dengue
keywords: Dengue
DeCS: Antivirais
Flavonoides
Flavanonas
Vírus da Dengue
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: FRABASILE, Sandra et al. The citrus flavanone naringenin impairs dengue virus replication in human cells. Scientific Reports, v. 7, n.41864, 2017.
DOI: https://doi.org/10.1038/srep41864
ISSN: 2045-2322
Copyright: open access
Appears in Collections:PR - ICC - Artigos de Periódicos

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