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Title: Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
Authors: Braga, Cynthia
Albuquerque, Maria de Fátima Pessoa Militão de
Cordeiro, Marli Tenório
Castanha, Priscila M. S.
Ramesh, Anita
Alexander, Neal
Mello, Maria Júlia G. de
Marques, Ernesto T. A.
Martelli, Celina M. Turchi
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
Abstract: Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis.
Keywords: Dengue
Dengue Virus
Epidemiologic Methods
Enzyme-Linked Immunosorbent Assay
Antibodies, Viral
Endemic Diseases
Child, Preschool
Immunity, Maternally-Acquired
Immunoglobulin G
Immunoglobulin M
keywords: Dengue
Vírus da Dengue
DeCS: Dengue
Vírus da dengue
Métodos Epidemiológicos
Anticorpos Antivirais
Doenças Endêmicas
Ensaio de Imunoadsorção Enzimática
Imunidade Materno-Adquirida
Imunoglobulina G
Imunoglobulina M
Issue Date: 2016
Citation: BRAGA, C. et al. Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results. Cadernos De Saude Publica, v. 32, n. 1, jan. 2016.
DOI: 10.1590/0102-311X00095815
ISSN: 1678-4464
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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