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CRITHIDIA DEANEI INFECTION IN NORMAL AND DEXAMETHASONE–IMMUNOSUPPRESSED BALB/C MICE
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Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular.. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular.. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular.. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ. Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular.. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ. Brasil.
Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular.. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular.. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ. Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular.. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ. Brasil.
Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.
Abstract
Monoxenous trypanossomatids protozoa are
not believed to cause in vivo infection in vertebrate
hosts throughout their life cycle. However,
there are reports mentioning some cases of HIVpositive
patients who have presented opportunistic
infections caused by these protozoa.
Recently, we have demonstrated the in vitro infection
of mouse dermal fibroblasts by these
protozoa. The aim of the present work is to investigate
the possibility of Crithidia deanei, a
endosymbiont-bearing monoxenous trypanossomatid,
infect BALB/c mice under or not
Dexamethasone treatment. To attend it, distinct
gro- ups of adult BALB/c mice were immunosuppressed
with 50 mg/kg of Dexamethasone.
This immunosuppressor was administered 24
hours before infection and daily, for 15 days
after C. deanei inoculation. Control groups: C.
deanei–inoculated animals but non-immunosuppressed
and non-inoculated animals but
immunosuppressed were also used. Light Microscopy
analysis revealed an infection process
characterized by the presence of the trypanossomatid
inside dermal cells in the groups studied.
The experimental inoculation resulted in a
non-lethal infection characterized by the presence
of the trypanossomatid inside dermal cells
in the normal BALB/c mice, but notably, in the C.
deanei–inoculated immunosuppressed group.
These preliminary results lead to the following
conclusions: 1) C. deanei is able to infect normal
BALB/c mice; 2) the immunosupressed
mice seemed to be more susceptible to the C.
deanei infection compared to the control group.
Besides C. deanei in dexamethasone-immunosuppressed
mice provides a useful model for
studies of monoxenous trypanosomatids ‘in
vivo’ infection, resembling that one presumably
occurring in imunodeficient individuals with
AIDS.
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