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DISTINCT GENOTYPIC PROFILES OF THE TWO MAJOR CLADES OF MYCOBACTERIUM AFRICANUM
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.
Columbia University Medical Center. New York- Presbyterian Hospital. Department of Pathology. Clinical Microbiology Service. New York City, NY, USA.
National Reference Center for Mycobacteria. Borstel, Germany.
National Institute for Public Health and the Environment. Mycobacteria Reference Laboratory. Bilthoven, The Netherlands.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.
Joan and Sanford I. Weill Medical College of Cornell University. Department of Medicine. Division of International Medicine and Infectious Diseases. New York City, NY, USA.
Columbia University Medical Center. New York- Presbyterian Hospital. Department of Pathology. Clinical Microbiology Service. New York City, NY, USA.
National Reference Center for Mycobacteria. Borstel, Germany.
National Institute for Public Health and the Environment. Mycobacteria Reference Laboratory. Bilthoven, The Netherlands.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.
Joan and Sanford I. Weill Medical College of Cornell University. Department of Medicine. Division of International Medicine and Infectious Diseases. New York City, NY, USA.
Abstract
Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis (TB) and a member of the M. tuberculosis complex (MTC). Additional MTC species that cause TB in humans and other mammals include Mycobacterium africanum and Mycobacterium bovis. One result of studies interrogating recently identified MTC phylogenetic markers has been the recognition of at least two distinct lineages of M. africanum, known as West African-1 and West African-2.
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