Author | Araujo, Luiza Ferreira de | |
Author | Fonseca, Aline Simonete | |
Author | Muys, Bruna Rodrigues | |
Author | Plaça, Jessica Rodrigues | |
Author | Bueno, Rafaela de Barros e Lima | |
Author | Lorenzi, Julio Cesar Cetrulo | |
Author | Santos, Anemari Ramos Dinarte dos | |
Author | Molfetta, Greice Andreotti de | |
Author | Zanette, Dalila Lucíola | |
Author | Souza, Jorge Estefano Santana de | |
Author | Valente, Valeria | |
Author | Silva Junior, Wilson Araujo da | |
Access date | 2017-09-11T19:41:06Z | |
Available date | 2017-09-11T19:41:06Z | |
Document date | 2015 | |
Citation | ARAUJO, L. F. et al. Mitochondrial genome instability in colorectal adenoma and adenocarcinoma. Tumor Biology, v. 36, n. 11, p. 8869-8879, 2015. | pt_BR |
ISSN | 1010-4283 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20949 | |
Description | Zanette, Dalila Lucíola “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | The National Council for Scientific and Technological Development (CNPq), grant #573754/2008-0; by
grants #2008/57877-3 and #2013/08135-2, São Paulo Research Foundation (FAPESP); and by Research Support of the University Sao Paulo, CISBi-NAP/USP #12.1.25441.01.2. | pt_BR |
Language | eng | pt_BR |
Publisher | Springer Verlag | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Genoma mitocondrial | pt_BR |
Subject in Portuguese | Câncer colorretal | pt_BR |
Subject in Portuguese | Heteroplasmia | pt_BR |
Subject in Portuguese | Instabilidade do genoma | pt_BR |
Title | Mitochondrial genome instability in colorectal adenoma and adenocarcinoma | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s13277-015-3640-7 | |
Abstract | Mitochondrial dysfunction is regarded as a hallmark of cancer progression. In the current study, we evaluated mitochondrial genome instability and copy number in colorectal cancer using Next Generation Sequencing approach and qPCR, respectively. The results revealed higher levels of heteroplasmy and depletion of the relative mtDNA copy number in colorectal adenocarcinoma. Adenocarcinoma samples also presented an increased number of mutations in nuclear genes encoding proteins which functions are related with mitochondria fusion, fission and localization. Moreover, we found a set of mitochondrial and nuclear genes, which cooperate in the same mitochondrial function simultaneously mutated in adenocarcinoma. In summary, these results support an important role for mitochondrial function and genomic instability in colorectal tumorigenesis. | pt_BR |
Affilliation | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, Brazil | pt_BR |
Affilliation | Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, Brazil / University of São Paulo State. Faculty of Pharmaceutical Science of Araraquara. Department of Clinical Analysis. Araraquara, SP, Brazil | pt_BR |
Affilliation | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, Brazil | pt_BR |
Subject | Mitochondrial genome | pt_BR |
Subject | Colorectal cancer | pt_BR |
Subject | Heteroplasmy | pt_BR |
Subject | Genome instability | pt_BR |