Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20983
Title: An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
Authors: Carels, Nicolas
Leon, Miguel Ponce de
Affilliation: Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
Universidad Complutense de Madrid. Facultad de Ciencias Químicas. Departamento de Bioquímica y Biología Molecular I. Madrid, Spain.
Abstract: Purine bias, which is usually referred to as an “ancestral codon”, is known to result in short-range correlations between nucleotides in coding sequences, and it is common in all species. We demonstrate that RW Y is a more appropriate pattern than the classical RNY, and purine bias (Rrr) is the product of a network of nucleotide compensations induced by functional constraints on the physicochemical properties of proteins. Through deductions from universal correlation properties, we also demonstrate that amino acids from Miller’s spark discharge experiment are compatible with functional primeval proteins at the dawn of living cell radiation on earth. These amino acids match the hydropathy and secondary structures of modern proteins.
Keywords: genomics
protein features
ancestral codon
purine bias
short-range correlations
keywords: genômica
características proteicas
codon ancestral
Issue Date: 2015
Publisher: SAGE Publishing
Citation: CARELS, N. et al. An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences. Bioinformatics and Biology Insights, v. 9, p. 37-47, 2015.
ISSN: 1177-9322
Copyright: open access
Appears in Collections:CDTS - Artigos de Periódicos

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