Author | Peixoto, Christina Alves | |
Author | Nunes, Ana Karolina Santana | |
Author | Garcia-Osta, Ana | |
Access date | 2017-09-12T19:35:23Z | |
Available date | 2017-09-12T19:35:23Z | |
Document date | 2015 | |
Citation | PEIXOTO, C. A.; NUNES, A. K. S.; GARCIA-OSTA, A. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation, v. 2015, p. 940207, 2015 | pt_BR |
ISSN | 1466-1861 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20991 | |
Language | por | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Cognição | pt_BR |
Subject in Portuguese | Degeneração Neural | pt_BR |
Subject in Portuguese | Neuroimunomodulação | pt_BR |
Subject in Portuguese | Inibidores da Fosfodiesterase 5 | pt_BR |
Title | Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2015/940207 | |
Abstract | Phosphodiesterase type 5 inhibitors (PDE5-Is) have recently emerged as a potential therapeutic strategy for neuroinflammatory, neurodegenerative, and memory loss diseases. Mechanistically, PDE5-Is produce an anti-inflammatory and neuroprotection effect by increasing expression of nitric oxide synthases and accumulation of cGMP and activating protein kinase G (PKG), the signaling pathway of which is thought to play an important role in the development of several neurodiseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The aim of this paper was to review present knowledge of the signaling pathways that underlie the use of PDE5-Is in neuroinflammation, neurogenesis, learning, and memory. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil | pt_BR |
Subject | Cognition | pt_BR |
Subject | Nerve Degeneration | pt_BR |
Subject | Neuroimmunomodulation | pt_BR |
Subject | Phosphodiesterase 5 Inhibitors | pt_BR |
Subject | Animals | pt_BR |
Subject | Blood-Brain Barrier | pt_BR |
Subject | Humans | pt_BR |
Subject | Mice | pt_BR |
Subject | Neuroglia | pt_BR |
Subject | Neurogenesis | pt_BR |
Subject | Neuroprotective Agents | pt_BR |
Subject | Nucleotides, Cyclic | pt_BR |
DeCS | Cognição | pt_BR |
DeCS | Degeneração Neural | pt_BR |
DeCS | Neuroimunomodulação | pt_BR |
DeCS | Inibidores da Fosfodiesterase 5 | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Barreira Hematoencefálica | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Neurogênese | pt_BR |
DeCS | Neuroglia | pt_BR |
DeCS | Fármacos Neuroprotetores | pt_BR |
DeCS | Nucleotídeos Cíclicos | pt_BR |