Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20991
Title: Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
Authors: Peixoto, Christina Alves
Nunes, Ana Karolina Santana
Garcia-Osta, Ana
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
Abstract: Phosphodiesterase type 5 inhibitors (PDE5-Is) have recently emerged as a potential therapeutic strategy for neuroinflammatory, neurodegenerative, and memory loss diseases. Mechanistically, PDE5-Is produce an anti-inflammatory and neuroprotection effect by increasing expression of nitric oxide synthases and accumulation of cGMP and activating protein kinase G (PKG), the signaling pathway of which is thought to play an important role in the development of several neurodiseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The aim of this paper was to review present knowledge of the signaling pathways that underlie the use of PDE5-Is in neuroinflammation, neurogenesis, learning, and memory.
Keywords: Cognition
Nerve Degeneration
Neuroimmunomodulation
Phosphodiesterase 5 Inhibitors
Animals
Blood-Brain Barrier
Humans
Mice
Neuroglia
Neurogenesis
Neuroprotective Agents
Nucleotides, Cyclic
keywords: Cognição
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
DeCS: Cognição
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Animais
Barreira Hematoencefálica
Humanos
Camundongos
Neurogênese
Neuroglia
Fármacos Neuroprotetores
Nucleotídeos Cíclicos
Issue Date: 2015
Citation: PEIXOTO, C. A.; NUNES, A. K. S.; GARCIA-OSTA, A. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation, v. 2015, p. 940207, 2015
DOI: 10.1155/2015/940207
ISSN: 1466-1861
Copyright: open access
Appears in Collections:IAM - Artigos de Periódicos

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