| Author | Paiva, Marcelo H. S. | |
| Author | Lovin, Diane D. | |
| Author | Mori, Akio | |
| Author | Melo-Santos, Maria A. V. | |
| Author | Severson, David W. | |
| Author | Ayres, Constância F. J. | |
| Access date | 2017-09-13T17:43:33Z | |
| Available date | 2017-09-13T17:43:33Z | |
| Document date | 2016 | |
| Citation | PAIVA, M. H. S. et al. Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti. Genomics, v. 107, n. 1, p. 40–48, jan. 2016. | pt_BR |
| ISSN | 1089-8646 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/21003 | |
| Language | por | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Aedes | pt_BR |
| Subject in Portuguese | Resistência a Inseticidas | pt_BR |
| Subject in Portuguese | Locos de Características Quantitativas | pt_BR |
| Title | Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti | pt_BR |
| Type | Article | pt_BR |
| Abstract | Organophosphate insecticides (OP) have extensively been used to control mosquitoes, such as the vector Aedes aegypti. Unfortunately, OP resistance has hampered control programs worldwide. We used Quantitative Trait Locus (QTL) mapping to evaluate temephos resistance in two F1 intercross populations derived from crosses between a resistant Ae. aegypti strain (RecR) and two susceptible strains (MoyoD and Red). A single major effect QTL was identified on chromosome 2 of both segregating populations, named rtt1 (resistance to temephos 1). Bioinformatics analyses identified a cluster of carboxylesterase genes (CCE) within the rtt1 interval. qRT-PCR demonstrated that different CCEs were up-regulated in F2 resistant individuals from both crosses. However, none exceeded the 2-fold expression. Primary mechanisms for temephos resistance may vary between Ae. aegypti populations, yet also appear to support previous findings suggesting that multiple linked esterase genes may contribute to temephos resistance in the RecR strain as well as other populations. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil | pt_BR |
| Subject | Aedes | pt_BR |
| Subject | drug effects | pt_BR |
| Subject | genetics | pt_BR |
| Subject | Animals | pt_BR |
| Subject | Chromosomes, Insect | pt_BR |
| Subject | Insecticide Resistance | pt_BR |
| Subject | Insecticides | pt_BR |
| Subject | Quantitative Trait Loci | pt_BR |
| Subject | Temefos | pt_BR |
| Subject | toxicity | pt_BR |
| DeCS | Aedes | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Cromossomos de Insetos | pt_BR |
| DeCS | Resistência a Inseticidas | pt_BR |
| DeCS | Inseticidas | pt_BR |
| DeCS | Locos de Características Quantitativas | pt_BR |
| DeCS | Temefós | pt_BR |
| e-ISSN | 10.1016/j.ygeno.2015.11.004 | |
