Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/21071
Title: Hepatocyte xenotransplantation for treating liver disease
Authors: Bonavita, André Gustavo
Quaresma, Kátia
Almeida, Vinícius Cotta de
Pinto, Marcelo Alves
Saraiva, Roberto Magalhães
Alves, Luiz Anastácio
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ. Brasil.
Abstract: The treatment of acute and chronic liver failure is still a challenge despite modern therapeutic innovations. While liver transplantation can restore liver function and improve patient survival, donor shortages limit this treatment to a small number of patients. Cellular xenotransplantation has emerged as an alternative for treating liver failure. Xenohepatocytes could be readily available in sufficient quantities to treat patients in critical condition and thereby reduce the donor shortage. The use of isolated encapsulated or non-encapsulated cells can reduce the immunorejection response. Several studies using animal models of acute or chronic liver failure have demonstrated improved survival and recovery of liver function after xenotransplantation of adult hepatocytes. Porcine liver cells are a potential source of xenohepatocytes due to similarities with human physiology and the great number of hepatocytes that can be obtained. The recent development of less immunogenic transgenic pigs, new immunosuppressive drugs, and cellular encapsulation systems represents important advances in the field of cellular xenotransplantation. In this study, we review the work carried out in animal models that deals with the advantages and limitations of hepatocyte xenotransplantation, and we propose new studies needed in this field.
Keywords: cell therapy
hepatocyte
liver disease
xenotransplantation
keywords: Terapia celular
Transplante Heterólogo
Doença do fígado
hepatócito
DeCS: Transplante Heterólogo
Issue Date: 2010
Publisher: Wiley
Citation: BONAVITA, A.ndré Gustavo; et al. Hepatocyte xenotransplantation for treating liver disease. Xenotransplantation, v.17, p.181–187, 2010.
DOI: 10.1111/j.1399-3089.2010.00588.x
ISSN: 0908-665X
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos
IOC - Artigos de Periódicos

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