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2030-01-01
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RFC-1 80G>A POLYMORPHISM IN CASE-MOTHER/CONTROL-MOTHER DYADS IS ASSOCIATED WITH RISK OF NEPHROBLASTOMA AND NEUROBLASTOMA
Azevedo, Rafaela Montalvão de et al. | Date Issued: 2015
Author
Azevedo, Rafaela Montalvão de
Vasconcelos, Gisele M.
Vargas, Fernando R.
Thuler, Luiz Claudio
Oliveira, Maria S. Pombo de
Camargo, Beatriz de
Affilliation
Instittuto Nacional de Câncer. Programa de Pesquisa em Hematologia e Oncologia Pediátrica. Rio de Janeiro, RJ, Brasil.
Instittuto Nacional de Câncer. Programa de Pesquisa em Hematologia e Oncologia Pediátrica. Rio de Janeiro, RJ, Brasil.
Instittuto Nacional de Câncer. Centro de Pesquisa. Programa de Genética. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Instittuto Nacional de Câncer. Centro de Pesquisa. Programa de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil
Instittuto Nacional de Câncer. Programa de Pesquisa em Hematologia e Oncologia Pediátrica. Rio de Janeiro, RJ, Brasil.
Instittuto Nacional de Câncer. Programa de Pesquisa em Hematologia e Oncologia Pediátrica. Rio de Janeiro, RJ, Brasil.
Abstract
Embryonic tumors are associated with an interruption during normal organ development; they may be related to disturbances in the folate pathway involved in DNA synthesis, methylation, and repair. Prenatal supplementation with folic acid is associated with a decreased risk of neuroblastoma, brain tumors, retinoblastoma, and nephroblastoma. The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.
Keywords in Portuguese
Nefroblastoma
Neuroblastoma
Câncer
Polimorfismo
 
Keywords
Nephroblastoma
Cancer
Embryonic tumors
polymorphism
 
Publisher
Mary Ann Liebert
Citation
AZEVEDO, Rafaela Montalvão de; et al. RFC-1 80G > A Polymorphism in Case-Mother/ Control-Mother Dyads Is Associated with Risk of Nephroblastoma and Neuroblastoma. Genetic Testing and Molecular Biomarkers, v.19, n.2, p.75-81, 2015.
DOI
10.1089/gtmb.2014.0177
ISSN
1945-0265
Notes
Acknowledgments for a listing of the Brazilian Embryonic Tumor Group.