Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/22777
Title: Quinic acid derivatives inhibit dengue virus replication in vitro
Authors: Zanello, Paula Rodrigues
Koishi, Andrea Cristine
Rezende Júnior, Celso de Oliveira
Oliveira, Larissa Albuquerque
Pereira, Adriane Antonia
Almeida, Mauro Vieira de
Santos, Claudia Nunes Duarte dos
Bordignon, Juliano
Affilliation: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.
Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.
Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.
Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Abstract: Dengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases and 25,000 deaths per year. Despite these numbers, neither a specific treatment nor a preventive vaccine is available to protect people living in areas of high risk. With the aim of seeking a treatment that can mitigate dengue infection, we demonstrated that the quinic acid derivatives known as compound 2 and compound 10 were effective against all four dengue virus serotypes and safe for use in a human hepatoma cell line (Huh7.5). Both compounds were non-virucidal to dengue virus particles and did not interfere with early steps of the dengue virus life cycle, including binding and internalization. Experiments using a replicon system demonstrated that compounds 2 and 10 impaired dengue virus replication in Huh7.5 cells. Additionally, the anti-dengue virus effects of the quinic acid derivatives were preserved in human peripheral blood mononuclear cells.Taken together, these data suggest that quinic acid derivatives represent a novel chemical class of active compounds that could be used to combat dengue virus infection.
Keywords: Virus Replication
Antiviral Agents
Quinic Acid
Keywords in spanish: Replicación Viral
Antivirales
keywords: Dengue
DeCS: Replicação Viral
Antivirais
Ácido Quínico
Issue Date: 2015
Publisher: BioMed Central
Citation: ZANELLO, Paula Rodrigues et al. Quinic acid derivatives inhibit dengue virus replication in vitro. Virology Journal, v. 12, n. 223, p. 1-13, 2015.
DOI: 10.1186/s12985-015-0443-9
ISSN: 1743-422X
Copyright: open access
Appears in Collections:PR - ICC - Artigos de Periódicos

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