Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/22818
Title: Coinfections of Zika and Chikungunya Viruses in Bahia, Brazil, Identified by Metagenomic Next-Generation Sequencing
Authors: Sardi, Silvia Ines
Somasekar, Sneha
Naccache, Samia N
Bandeira, Antonio Carlos
Tauro, Laura Beatriz
Campos, Gubio Soares
Chiu, Charles Y
Affilliation: University Federal of Bahia. Health Institute of Science. Laboratory of Virology. Salvador, Bahia, Brazil
University of California. Department of Laboratory Medicine. San Francisco, California, USA / UCSF-Abbott Viral Diagnostics and Discovery Center. San Francisco, California, USA
University of California. Department of Laboratory Medicine. San Francisco, California, USA / UCSF-Abbott Viral Diagnostics and Discovery Center. San Francisco, California, USA
Aliança Hospital. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University Federal of Bahia. Health Institute of Science. Laboratory of Virology. Salvador, Bahia, Brazil
University of California. Department of Laboratory Medicine. San Francisco, California, USA / UCSF-Abbott Viral Diagnostics and Discovery Center. San Francisco, California, USA / University of California,. Department of Medicine, Division of Infectious Diseases. San Francisco, California, USAf
Abstract: Metagenomic next-generation sequencing (mNGS) of samples from 15 patients with documented Zika virus (ZIKV) infection in Bahia, Brazil, from April 2015 to January 2016 identified coinfections with chikungunya virus (CHIKV) in 2 of 15 ZIKV-positive cases by PCR (13.3%). While generally nonspecific, the clinical presentation corresponding to these two CHIKV/ZIKV coinfections reflected infection by the virus present at a higher titer. Aside from CHIKV and ZIKV, coinfections of other viral pathogens were not detected. The mNGS approach is promising for differential diagnosis of acute febrile illness and identification of coinfections, although targeted arbovirus screening may be sufficient in the current ZIKV outbreak setting.
Keywords: Zika Virus
Zika Virus Infection
Chikungunya Fever
Chikungunya virus
Coinfection
Metagenomics
Humans
Adult
Brazil
keywords: Virus Zika
Infecção por vírus Zika
Febre Chikungunya
Virus Chikungunya
Infecção
Metagenômica
Humanos
Adulto
Brasil
Issue Date: 2016
Publisher: American Society for Microbiology
Citation: SARDI, S. I. et al. Coinfections of Zika and Chikungunya Viruses in Bahia, Brazil, Identified by Metagenomic Next-Generation Sequencing. Journal of Clinical Microbiology, v. 54, n. 9, p. 2348 –2353, 2016.
DOI: 10.1128/JCM.00877-16
ISSN: 0095-1137
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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