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NEUROLOGIC COMPLICATIONS ASSOCIATED WITH THE ZIKA VIRUS IN BRAZILIAN ADULTS
Author
Affilliation
Americas Medical City. Neurology Department. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Departamento de Neurologia. Niterói, RJ, Brasil. .
New York University. Department of Neurology. New York, NY, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Falvivírus. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Neurologia. Niterói, RJ, Brasil.
New York University. Department of Neurology. New York, NY, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Falvivírus. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Neurologia. Niterói, RJ, Brasil.
Abstract
Zika virus (ZIKV) is a flavivirus related to the dengue, yellow
fever, andWest Nile viruses and is transmitted by
the Aedes mosquito species. In July 2015, 76 patients
with neurologic syndromes and recent symptoms suggestive
of ZIKV infection were identified in the state of Bahia, Brazil,
of which 42 (55%) had confirmed Guillain-Barré syndrome
(GBS).1 By July 2016, a total of 165 932 suspected cases of ZIKV
infectionwere reportedtothe Brazilian MinistryofHealth,with
66 180 confirmed cases in 1850 cities and 22 of 26 states (incidence
rate, 81.2 cases per 100000 inhabitants).2 It is speculated
that 500000 to 1.5 million people might have been infectedwith
ZIKV in Brazil since the beginning of the outbreak.3
The first cases of mosquito-transmitted ZIKV in the United
States were reported in July 2016.4 Despite concomitant increases
in the incidence of both GBS5 and ZIKV in Brazil, the
links to neurologic complications in adults have been limited
to case series on GBS,6,7 meningoencephalitis,8 transverse
myelitis,9 and ophthalmologic disease.10
We aimed to prospectively evaluate adult patients with
neurologic syndromes consistentwith GBS, transversemyelitis,
or meningoencephalitis for molecular and serologic evidence
of recent ZIKV infection. We also compared radiographic
and electrophysiological findings and functional
outcomes between patients positive for ZIKV infection and
those negative for ZIKV infectionwhowereadmittedwith each
syndrome.
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