| Author | Silva Junior, Jailton de Azevedo | |
| Author | Anjos, Eder Silva dos | |
| Author | Cordeiro, Soraia Machado | |
| Author | Santos, Milena Soares dos | |
| Author | Escobar, Eliane C | |
| Author | Lobo, Paulo Rocha | |
| Author | Carvalho, Maria da Gloria | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Reis, Joice Neves | |
| Author | Campos, Leila Carvalho | |
| Access date | 2017-10-23T19:38:34Z | |
| Available date | 2017-10-23T19:38:34Z | |
| Document date | 2016 | |
| Citation | SILVA JUNIOR, J. A. et al. Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil. Journal of Medical Microbiology, v. 65, p. 1164–1170, 2016. | pt_BR |
| ISSN | 0022-2615 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/22909 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (483674/2010-9) and Fundação Oswaldo Cruz (PAPES 407551/2012-3). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Microbiology Society | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Streptococcus pneumoniae | pt_BR |
| Subject in Portuguese | Vacinas pneumocócicas | pt_BR |
| Subject in Portuguese | Meningite, pneumococo | pt_BR |
| Subject in Portuguese | Variação genética | pt_BR |
| Subject in Portuguese | Serotipagem | pt_BR |
| Subject in Portuguese | Adolescente | pt_BR |
| Subject in Portuguese | Adulto | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1099/jmm.0.000346 | |
| Abstract | In 2010, the 10-valent pneumococcal conjugate vaccine (PCV10) was introduced into the Brazilian childhood vaccination programme. Concerns have been raised that non-vaccine serotypes could increase in prevalence and reduce the benefits of vaccination; therefore, we examined non-PCV10 isolates recovered from meningitis during pre- (January 2008-May 2010) and post-vaccine (June 2010-December 2012) periods. Surveillance for pneumococcal meningitis was established at the Reference Hospital of Infectious Diseases in Salvador, Brazil. Serotypes were determined by multiplex PCR and/or Quellung reaction. Antimicrobial susceptibility testing was conducted by E-test and broth microdilution. Genotyping used PFGE and multi-locus sequence typing. A total of 148 cases of meningitis were identified from January 2008 to December 2012, 77 (52 %) of which were due to non-PCV10 isolates, with 50 (52.1 %) from pre-vaccine and 27 (52 %) from post-vaccine periods. In the post-vaccine period, the non-PCV10 serotypes 12F (n=6; 22.2 %), 10A (n=3; 11.1 %), 15B (n=2; 7.4 %) and 18B (n=2; 7.4 %) were the most prevalent. Forty-three isolates (55.8 %) were non-susceptible to one or more antibiotics. Non-susceptibility to penicillin was observed among serotypes 19A (three isolates), 9N (one isolate) and 12F (one isolate). PFGE and multi-locus sequence typing results demonstrated a wide genetic diversity among the isolates. During the early period following PCV10 introduction, no obvious emergence of a particular serotype was evident among non-PCV10 strains. This study underscores the importance of monitoring any changes among non-PCV10 cases after the introduction of PCV10. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Respiratory Diseases Branch. Centers for Disease Control and Prevention. Atlanta, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | Streptococcus pneumoniae | pt_BR |
| Subject | Pneumococcal Vaccines | pt_BR |
| Subject | Meningitis, Pneumococcal | pt_BR |
| Subject | Genetic Variation | pt_BR |
| Subject | Serotyping | pt_BR |
| Subject | Adolescent | pt_BR |
| Subject | Adult | pt_BR |
| Subject | Brazil | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
