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2030-01-01
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- IOC - Artigos de Periódicos [12488]
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INTEGRATED PATHWAYS FOR NEUTROPHIL RECRUITMENT AND INFLAMMATION IN LEPROSY
Mycobacterium leprae
Neutrófilos
Complexo Antígeno-Anticorpo
Receptores Toll-Like
Author
Affilliation
David Geffen School of Medicine at University of California. Department of Medicine. Division of Dermatology, Los Angeles, CA, USA .
University of California. UCLA-DOE Institute for Genomics and Proteomics. Los Angeles, CA, USA.
David Geffen School of Medicine at University of California. Department of Medicine. Division of Dermatology, Los Angeles, CA, USA.
Kioto University. Viral Oncology Institute for Virus Research. Department of Cell Regulation. Kyoto, Japan.
David Geffen School of Medicine at University of California. Department of Medicine. Division of Dermatology, Los Angeles, CA, USA.
University of California. Molecular Screening Shared Resource. Los Angeles, CA, USA.
University of Miami. Department of Dermatology and Cutaneous Surgery. Miami, FL, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
University of Southern California School of Medicine. Department of Dermatology. Los Angeles, CA, USA.
David Geffen School of Medicine at University of California. Department of Medicine. Division of Dermatology, Los Angeles, CA, USA / University of Southern California School of Medicine. Department of Dermatology. Los Angeles, CA, USA.
University of California. UCLA-DOE Institute for Genomics and Proteomics. Los Angeles, CA, USA.
David Geffen School of Medicine at University of California. Department of Medicine. Division of Dermatology, Los Angeles, CA, USA.
Kioto University. Viral Oncology Institute for Virus Research. Department of Cell Regulation. Kyoto, Japan.
David Geffen School of Medicine at University of California. Department of Medicine. Division of Dermatology, Los Angeles, CA, USA.
University of California. Molecular Screening Shared Resource. Los Angeles, CA, USA.
University of Miami. Department of Dermatology and Cutaneous Surgery. Miami, FL, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
University of Southern California School of Medicine. Department of Dermatology. Los Angeles, CA, USA.
David Geffen School of Medicine at University of California. Department of Medicine. Division of Dermatology, Los Angeles, CA, USA / University of Southern California School of Medicine. Department of Dermatology. Los Angeles, CA, USA.
Abstract
Neutrophil recruitment is pivotal to the host defense against microbial infection, but it also contributes to the immunopathology of disease. We investigated the mechanism of neutrophil recruitment in human infectious disease by means of bioinformatic pathways analysis of the gene expression profiles in the skin lesions of leprosy. In erythema nodosum leprosum (ENL), which occurs in patients with lepromatous leprosy and is characterized by neutrophil infiltration in lesions, the most overrepresented biological functional group was cell movement, including E-selectin, which was coordinately regulated with interleukin 1beta (IL-1beta). In vitro activation of Toll-like receptor 2 (TLR2), up-regulated in ENL lesions, triggered induction of IL-1beta, which together with interferon gamma induced E-selectin expression on and neutrophil adhesion to endothelial cells. Thalidomide, an effective treatment for ENL, inhibited this neutrophil recruitment pathway. The gene expression profile of ENL lesions comprised an integrated pathway of TLR2 and Fc receptor activation, neutrophil migration, and inflammation, providing insight into mechanisms of neutrophil recruitment in human infectious disease.
Keywords in Portuguese
HanseníaseMycobacterium leprae
Neutrófilos
Complexo Antígeno-Anticorpo
Receptores Toll-Like
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