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ANTI-CYTOKINE AUTOANTIBODIES ARE ASSOCIATED WITH OPPORTUNISTIC INFECTION IN PATIENTS WITH THYMIC NEOPLASIA
Burbelo, Peter D. et al. | Date Issued: 2010
Author
Burbelo, Peter D.
Browne, Sarah K.
Sampaio, Elizabeth P.
Giaccone, Giuseppe
Zaman, Rifat
Kristosturyan, Ervand
Rajan, Arun
Ding, Li
Ching, Kathryn H.
Berman, Arlene
Oliveira, Joao B.
Hsu, Amy P.
Klimavicz, Caitlin M.
Iadarola, Michael J.
Holland, Steven M.
Affilliation
National Institutes of Health. National Institute of Dental and Craniofacial Research. Laboratory of Sensory Biology. Neurobiology and Pain Therapeutics. Bethesda, MD, USA.
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Infectious Diseases. Bethesda, MA, USA.
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Infectious Diseases. Bethesda, MA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
National Institutes of Health. National Cancer Instittute. Medical Oncology Branch. Bethesda, MD, USA.
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Infectious Diseases. Bethesda, MA, USA.
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Infectious Diseases. Bethesda, MA, USA.
National Institutes of Health. National Cancer Instittute. Medical Oncology Branch. Bethesda, MD, USA.
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Infectious Diseases. Bethesda, MA, USA.
National Institutes of Health. National Institute of Dental and Craniofacial Research. Laboratory of Sensory Biology. Neurobiology and Pain Therapeutics. Bethesda, MD, USA.
National Institutes of Health. National Cancer Instittute. Medical Oncology Branch. Bethesda, MD, USA.
National Institutes of Health. Department of Laboratory Medicine. Immunology Service. Bethesda, MD, USA.
National Institutes of Health. National Institute of Dental and Craniofacial Research. Laboratory of Sensory Biology. Neurobiology and Pain Therapeutics. Bethesda, MD, USA.
National Institutes of Health. National Institute of Dental and Craniofacial Research. Laboratory of Sensory Biology. Neurobiology and Pain Therapeutics. Bethesda, MD, USA.
National Institutes of Health. National Institute of Dental and Craniofacial Research. Laboratory of Sensory Biology. Neurobiology and Pain Therapeutics. Bethesda, MD, USA.
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Infectious Diseases. Bethesda, MA, USA.
Abstract
Patients with thymic malignancy have high rates of autoimmunity leading to a variety of autoimmune diseases, most commonly myasthenia gravis caused by anti-acetylcholine receptor autoantibodies. High rates of autoantibodies to cytokines have also been described, although prevalence, spectrum, and functionality of these anti-cytokine autoantibodies are poorly defined. To better understand the presence and function of anti-cytokine autoantibodies, we created a luciferase immunoprecipitation system panel to search for autoantibodies against 39 different cytokines and examined plasma from controls (n = 30) and patients with thymic neoplasia (n = 17). In this screen, our patients showed statistically elevated, but highly heterogeneous immunoreactivity against 16 of the 39 cytokines. Some patients showed autoantibodies to multiple cytokines. Functional testing proved that autoantibodies directed against interferon-α, interferon-β, interleukin-1α (IL-1α), IL-12p35, IL-12p40, and IL-17A had biologic blocking activity in vitro. All patients with opportunistic infection showed multiple anti-cytokine autoantibodies (range 3-11), suggesting that anti-cytokine autoantibodies may be important in the pathogenesis of opportunistic infections in patients with thymic malignancy. This study was registered at http://clinicaltrials.gov as NCT00001355.
Keywords in Portuguese
Anti-citocinas
Autoanticorpos
Infecção oportunista
Neoplasia tímica
 
Keywords
Anti-cytokine autoantibodies
thymic neoplasia
opportunistic infection
 
Publisher
American Society of Hematology
Citation
BURBELO, Peter D. et al. Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia. Blood, v. 116, n. 29, p. 4848-4858, Dec. 2010.
DOI
10.1182/blood-2010-05-286161
ISSN
0006-4971