Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23011
Title: Hepatitis C virus infection in patients with tuberculosis in Central Brazil
Authors: Reis, N. R. S.
Lopes, C. L. R.
Teles, S. A.
Matos, M. A .D.
Carneiro, M. A. S.
Marinho, T. A.
Filho, J. A. Araújo
Espírito Santo, M. P.
Lampe, E.
Martins, R. M. B.
Affilliation: Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil / Hospital de Doenças Tropicais.Anuar Auad. Goiânia, GO, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Abstract: OBJECTIVES: To determine the prevalence of hepatitis C virus (HCV) infection, risk factors, HCV genotype/ subtype, HCV viral load and human immunodefi ciency virus (HIV) status in patients with tuberculosis (TB) in Central Brazil. DESIGN: A cross-sectional study was carried out with 402 patients who were under tuberculosis (TB) treatment in the reference hospital for infectious diseases in Goiânia, Goiás, Central Brazil. RESULTS: The prevalence rates of HCV and HIV were respectively 7.5% and 27.6%. Two thirds of the HCVinfected patients (20/30) were HIV-positive. Age, injecting drug use (IDU) and HIV status were factors independently associated with HCV infection. HCV RNA was detected in 23 serum samples; HCV RNA levels were measured in 22/23 samples. HCV RNA level was slightly higher in HCV-HIV co-infected patients than in HCV monoinfected patients. Genotypes 1 (n = 17) and 3 (n = 6) were determined by LiPA. Using phylogenetic tree analysis of the NS5B region, subtypes 1a (n = 12), 1b (n = 2) and 3a (n = 6) were identifi ed. CONCLUSION: These data indicate that patients with TB may benefi t from integrated HIV and HCV screening, which may have an important impact upon TB management and treatment..
Keywords: tuberculosis
hepatitis C virus
epidemic
Brazil
keywords: Tuberculose
Vírus da hepatite C
Epidemiologia
Brasil
Issue Date: 2011
Publisher: International Union Against Tuberculosis and Lung Disease
Citation: REIS, N. R. S. et al. Hepatitis C virus infection in patients with tuberculosis in Central Brazil. Int. J. Tuberc. Lung Dis., v. 15, n. 10, p.1397-1402, 2011.
DOI: 10.5588/ijtld.10.0636
ISSN: 1027-3719
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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