Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23083
Title: Next-generation sequencing virulome analysis of a Yersinia enterocolitica subsp. palearctica bioserotype 4/O:3 ST18 isolated from human blood in Brazil
Authors: Rusak, Leonardo Alves
Junqueira, Ricardo Magrani
Hofer, Ernesto
Valim, Deyse Christina
Asensi, Marise Dutra
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Zoonoses Bacterianas/Setor Listeria. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Zoonoses Bacterianas/Setor Listeria. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.
Abstract: tYersinia enterocolitica is a widespread Gram-negative bacterium that causes gastrointestinaldisease and other clinical manifestations in humans. Potentially pathogenic Y. enterocoliticahas been isolated in Brazil, from human, environmental, food, and animal sources. Hereinwe report a genome sequence of Y. enterocolitica subsp. palearctica strain YE 19, serotypeO:3, biotype 4, sequence type 18, with virulence determinants isolated from human bloodin Rio de Janeiro in 2005. The results corroborate other findings that this strain harbors aset of virulence determinants that could play a role in host pathoadaptation and may alsojustify the successful dissemination of bioserotype 4/O:3 in Brazil. The presence of strainsharboring all of these virulence genes in Brazil is a potential threat to young children andimmunocompromised individuals, for whom yersiniosis are a significant source of morbid-ity and mortality. The results of a genomic data analysis will help understand the virulenceof Brazilian strains and provide data for Y. enterocolitica studies worldwide.
Keywords: Yersinia enterocolitica
Virulence
Brazil
Next-generation sequencing
keywords: Seqüenciamento da próxima geração
Yersinia enterocolitica
Virulência
Brasil
Issue Date: 2017
Publisher: Sociedade Brasileira de Infectologia
Citation: RUSAK, Leonardo Alves; et al. Next-generation sequencing virulome analysis of a Yersinia enterocolitica subsp. palearctica bioserotype 4/O:3 ST18 isolated from human blood in Brazil. Braz J. Infect Dis., v.21, n.5, p.550-553, 2017
ISSN: 1413-8670
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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