| Author | Costa, Renata Albuquerque | |
| Author | Sousa, Oscarina Viana de | |
| Author | Hofer, Ernesto | |
| Author | Mafezoli, Jair | |
| Author | Barbosa, Francisco Geraldo | |
| Author | Vieira, Regine Helena Silva dos Fernandes | |
| Access date | 2017-11-09T11:34:16Z | |
| Available date | 2017-11-09T11:34:16Z | |
| Document date | 2017 | |
| Citation | COSTA, Renata Albuquerque; et al. Thiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species. BioMed Research International, Volume 2017, Article ID7963747, 6p, 2017. | pt_BR |
| ISSN | 2314-6133 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23087 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Moringa oleifera | pt_BR |
| Subject in Portuguese | Resistência a múltiplos medicamentos | pt_BR |
| Subject in Portuguese | Tiocarbamatos | pt_BR |
| Title | Thiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2017/7963747 | |
| Abstract | Prospect of antibacterial agents may provide an alternative therapy for diseases caused by multidrug-resistant bacteria. This study aimed to evaluate the in vitro bioactivity of Moringa oleifera seed extracts against 100 vibrios isolated from the marine shrimp Litopenaeus vannamei. Ethanol extracts at low (MOS-E) and hot (MOS-ES) temperature are shown to be bioactive against 92% and 90% of the strains, respectively. The most efficient Minimum Inhibitory Concentration (MIC) levels of MOS-E and MOS-ES against a high percentage of strains were 32 µg mL(-1). Bioguided screening of bioactive compounds showed that the ethyl acetate fraction from both extracts was the only one that showed antibacterial activity. Vibriocidal substances, niazirine and niazimicine, were isolated from the aforementioned fraction through chromatographic fractionation. | pt_BR |
| Affilliation | Universidade Federal do Ceará. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Ceará. Instituto de Ciências do Mar. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Ceará. Instituto de Ciências do Mar. Fortaleza, CE, Brasil. | pt_BR |
| Subject | Moringa oleifera | pt_BR |
| Subject | Multidrug-Resistant | pt_BR |
| Subject | Thiocarbamates | pt_BR |
| e-ISSN | 2314-6141 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
