Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23087
Title: Thiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species
Authors: Costa, Renata Albuquerque
Sousa, Oscarina Viana de
Hofer, Ernesto
Mafezoli, Jair
Barbosa, Francisco Geraldo
Vieira, Regine Helena Silva dos Fernandes
Affilliation: Universidade Federal do Ceará. Fortaleza, CE, Brasil.
Universidade Federal do Ceará. Instituto de Ciências do Mar. Fortaleza, CE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza, CE, Brasil.
Universidade Federal do Ceará. Instituto de Ciências do Mar. Fortaleza, CE, Brasil.
Abstract: Prospect of antibacterial agents may provide an alternative therapy for diseases caused by multidrug-resistant bacteria. This study aimed to evaluate the in vitro bioactivity of Moringa oleifera seed extracts against 100 vibrios isolated from the marine shrimp Litopenaeus vannamei. Ethanol extracts at low (MOS-E) and hot (MOS-ES) temperature are shown to be bioactive against 92% and 90% of the strains, respectively. The most efficient Minimum Inhibitory Concentration (MIC) levels of MOS-E and MOS-ES against a high percentage of strains were 32 µg mL(-1). Bioguided screening of bioactive compounds showed that the ethyl acetate fraction from both extracts was the only one that showed antibacterial activity. Vibriocidal substances, niazirine and niazimicine, were isolated from the aforementioned fraction through chromatographic fractionation.
Keywords: Moringa oleifera
Multidrug-Resistant
Thiocarbamates
keywords: Moringa oleifera
Resistência a múltiplos medicamentos
Tiocarbamatos
Issue Date: 2017
Publisher: Hindawi Publishing Corporation
Citation: COSTA, Renata Albuquerque; et al. Thiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species. BioMed Research International, Volume 2017, Article ID7963747, 6p, 2017.
DOI: 10.1155/2017/7963747
ISSN: 2314-6133
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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