Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23125
Title: Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia
Authors: Nicol, Alcina F.
Tugizov, Sharof M.
Herrera, Rossana
Grinsztejn, Beatriz
Friedman, Ruth K.
Veloso, Valdilea G.
Cunha, Cynthia B.
A., Chein
Wechsler, Erin Isaacson
Costa, Maria da
Palefsky, Joel M.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
University of California. Department of Medicine. San Francisco, CA, United States.
University of California. Department of Medicine. San Francisco, CA, United States.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
University of California. Department of Medicine. San Francisco, CA, United States.
University of California. Department of Medicine. San Francisco, CA, United States.
University of California. Department of Medicine. San Francisco, CA, United States.
University of California. Department of Medicine. San Francisco, CA, United States.
Abstract: Background: Claudin-1 expression is poorly characterized in anal intraepithelial neoplasia (AIN) from HIVpositive individuals. Aim: To investigate claudin-1 in situ expression in HPV-positive AIN lesions from HIV-positive individuals compared with non-dysplastic anal tissues. Materials and Methods: By means of immunofluorescence microscopy, claudin-1 was analyzed in 46 anal tissues: 18 AIN1; 14 AIN2/3 and 14 non-dysplastic specimens. Results: A higher proportion of cells with overexpression of claudin-1 were found in HIV-positive AIN lesions compared with controls. Overexpression of claudin-1 was most evident in AIN 2/3 lesions. HPV16 was detected in 21.8% anal specimens and HPV18 in 3.1%. A great diversity of 18 low-risk HPV types were detected, 40% of AIN specimens had multiple HPV types. Conclusions: Our data show that there is an over-expression of claudin-1 in HIV-positive AIN lesions compared with non-dysplastic anal biopsies. A high prevalence of HPV16 and diversity of HPV types was detected. The overexpression of claudin-1 in HIV-positive AIN specimens may play a role on the development of anal cancer, however further studies should be performed to better understand the role of claudin-1 in AIN and anal cancer development in the HIV-positive individuals.
Keywords: HPV
HIV-1
Claudin-1
Anal Dysplasia
Men Who Have Sex With Men
Women
keywords: HPV
HIV-1
Claudin-1
Displasia Anal
Homens que Fazem Sexo com Homens
Mulheres
DeCS: Papillomaviridae
HIV-1
Issue Date: 2017
Publisher: e-Century Publishing
Citation: NICOL, Alcina F. etal. Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia. International Journal of Clinical and Experimental Pathology, v. 10, n. 6, p. 6946-6955, 2017.
ISSN: 1936-2625
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
INI - Artigos de Periódicos

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