Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23129
Title: Factors associated with non-adherence to antiretroviral therapy in adults with AIDS in the first six months of treatment in Salvador, Bahia State, Brazil
Other Titles: Fatores associados à não adesão aos antirretrovirais em adultos com AIDS nos seis primeiros meses da terapia em Salvador, Bahia, Brasil
Factors associated with non-adherence to antiretroviral therapy in adults with AIDS in the first six months of treatment in Salvador, Bahia State, Brazil
Authors: Silva, José Adriano Góes
Dourado, Inês
Brito, Ana Maria de
Silva, Carlos Alberto Lima da
Affilliation: Centro Estadual Especializado em Diagnostico, Assistencia e Pesquisa, Salvador, Brasil
Instituto de Saude Coletiva, Universidade Federal da Bahia, Salvado, Brasil
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
Abstract: The control of viral replication is essential in the highly active antiretroviral therapy (HAART), and adherence to therapy is instrumental for such control. Individual and external factors influence adhesion to the use of antiretroviral (ARV) drugs. This is a cross-sectional study to investigate factors associated with non-adherence to HAART in AIDS patients in Salvador, Bahia State, Brazil, with age ≥ 13 years and first prescription in 2009. Data was collected from patient charts and pharmacy records. From a total of 216 patients, 65.3% were males; mean age 37.8 ± 9.5 years; single, 67.9%; heterosexual, 64%; more than 8 years of school education, 65.3%; alcohol users, 61.5%; non-smokers, 75,1% or non-illicit drug users, 93.7%. A proportion of 94% started ARV therapy with TCD4+ < 350 cells/mm3; 61.8% were symptomatic; and 68.4% had an adverse drug reaction. The prevalence of non-adherence was 25%. The variables associated were: longer time between HIV infection and AIDS (aOR = 3.9), adverse drug reaction (aOR = 2.4), under 34 years of age (aOR = 2.2), less than 8 years of school education (aOR = 2.2) and illicit drugs use (aOR = 2.6). A high-non-adherence rate is an important problem within the first six months of HAART.
Keywords: Acquired Immunodeficiency Syndrome
Adolescent
Adult
Age Factors
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Brazil
Cross-Sectional Studies
Female
HIV Infections
Humans
Male
Medication Adherence
Patient Compliance
Sex Factors
Socioeconomic Factors
keywords: Síndrome de Imunodeficiência Adquirida
Fármacos Anti-HIV
Terapia Antirretroviral de Alta Atividade
Adesão à Medicação
DeCS: Síndrome de Imunodeficiência Adquirida
tratamento farmacológico
Adolescente
Adulto
Fatores etários
Fármacos Anti-HIV
uso terapêutico
Terapia Antirretroviral de Alta Atividade
Brasil
Estudos Transversais
Feminino
Masculino
Humanos
Infecções por HIV
Adesão à Medicação
estatística & dados numéricos
Cooperação do Paciente
Fatores Sexuais
Fatores Socioeconômicos
Issue Date: 2015
Citation: SILVA, J. A. G. et al. Factors associated with non-adherence to antiretroviral therapy in adults with AIDS in the first six months of treatment in Salvador, Bahia State, Brazil. Cadernos De Saude Publica, v. 31, n. 6, p. 1188–1198, jun. 2015.
DOI: 10.1590/0102-311X00106914
ISSN: 1678-4464
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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