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CD64 EXPRESSION ON POLYMORPHONUCLEAR CELLS AS A POTENTIAL MARKER FOR MONITORING THE HUMAN CYTOMEGALOVIRUS REPLICATION AFTER KIDNEY TRANSPLANTATION
Alternative title
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantationAuthor
Affilliation
Abstract in Portuguese
A infecção por citomegalovírus humano (CMVH) é a principal causa de morbidade em receptores de transplante renal.
Este estudo pretende investigar se a expressão de CD64 em polimorfonucleares (PMN) é útil para a detecção de infecção
por CMVH em 11 receptores renais durante 60 dias. Do total de pacientes, nove foram positivos para antigenemia pp65
e para CMVH por reação em cadeia da polimerase quantitativa (qPCR), todos apresentando neutrófilos circulantes que
expressam CD64 3-4 semanas antes do pico de antigenemia pp65. Esses resultados sugerem que a quantificação de
PMN CD64 em conjunto com a antigenemia pp65 pode ser útil para o diagnóstico precoce de HCMV no pós-transplante.
Abstract
Human cytomegalovirus (HCMV) infection is the main cause of morbidity in kidney transplant recipients. This study aims to investigate if
CD64 expression on polymorphonuclear (PMN) cells is useful for the detection of HCMV infection in eleven kidney recipients during sixty
days. From the total patients, nine were positive for both pp65 antigenemia and HCMV by quantitative polymerase chain reaction (qPCR), all
of which had circulating neutrophils expressing CD64 3-4 weeks prior to pp65 antigenemia peak. These results suggest that quantification
of PMN CD64 together with pp65 antigenemia could be useful for the early diagnosis of HCMV after transplantation.
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