Author | Nogueira, Mauricio Lacerda | |
Author | Nery Júnior, Nivison Ruy Rocha | |
Author | Estofolete, Cássia Fernanda | |
Author | Terzian, Ana Carolina Bernardes | |
Author | Guimarães, Georgia de Freitas | |
Author | Zini, Nathalia | |
Author | Silva, Rafael Alves da | |
Author | Silva, Gislaine Celestino Dutra | |
Author | Franco, Ligia Cosentino Junqueira | |
Author | Rahal, Paula | |
Author | Bittar, Cintia | |
Author | Carneiro, Bruno | |
Author | Costa, Pedro Fernando Vasconcelos da | |
Author | Henriques, Daniele Freitas | |
Author | Barbosa, Deusenia Machado Ulisses | |
Author | Rombola, Patrícia Lopes | |
Author | Grande, Luciana de | |
Author | Reis, Andréia Francesli Negri | |
Author | Palomares, Sacha Ariane | |
Author | Catelan, Marcia Wakai | |
Author | Cruz, Lilian Elisa Arão Antonio | |
Author | Necchi, Silvia Helena | |
Author | Mendonça, Rita de Cassia Vilella | |
Author | Santos, Izalco Nuremberg Penha dos | |
Author | Caron, Suzimeiri Brigatti Alavarse | |
Author | Costa, Federico | |
Author | Bozza, Fernando A | |
Author | Souza, Antonio Soares de | |
Author | Mattos, Cinara Cássia Brandão de | |
Author | Mattos, Luiz Carlos de | |
Author | Vasilakis, Nikos | |
Author | Oliani, Antonio Helio | |
Author | Oliani, Denise Cristina Mós Vaz | |
Author | Ko, Albert Icksang | |
Access date | 2017-11-17T12:43:36Z | |
Available date | 2017-11-17T12:43:36Z | |
Document date | 2017 | |
Citation | NOGUEIRA, M. L. et al. Adverse birth outcomes associated with Zika virus exposure during pregnancy in São José do Rio Preto, Brazil. Clinical Microbiology and Infection, p. 1-45, 2017. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/23254 | |
Sponsorship | The São Paulo Research Foundation (FAPESP) via Grant 262 No. 2013/21719-3 and 2016/15021-1for M.L.N, Grant No. 2015/12295-0 for A.C.B.T., and Grant 263 No. 2016/05115-9 for L.C.M. P.F.C.V. was supported by the Zika Virus Fast Track program pro264 vided by the Association for the Improvement of Higher Education Personnel (CAPES) and the 265 Brazilian National Council for Scientific and Technological Development (CNPq) via Grant Nos. 266 303999/2016-0, 440405/2016-5, and 457664/2013-4. MLM is a CNPq Research Fellow. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Zika Virus | pt_BR |
Subject in Portuguese | Gravidez | pt_BR |
Subject in Portuguese | Dengue | pt_BR |
Subject in Portuguese | Infecção por Zika Virus | pt_BR |
Subject in Portuguese | Gestantes | pt_BR |
Subject in Portuguese | Dengue | pt_BR |
Subject in Portuguese | Saúde Pública | pt_BR |
Subject in Portuguese | Recem-nascido | pt_BR |
Subject in Portuguese | Microcefalia | pt_BR |
Title | Adverse birth outcomes associated with Zika virus exposure during pregnancy in São José do Rio Preto, Brazil | pt_BR |
Type | Preprint | pt_BR |
DOI | 10.1016/j.cmi.2017.11.004 | pt_BR |
Abstract | Objective: We aimed to report the first 54 cases of pregnant women infected by Zika vírus (ZIKV) and their virological and clinical outcomes, as well as the newborns’ outcomes in 2016, after the emergence of ZIKV in dengue endemic areas of São Paulo, Brazil. Methods: This is a descriptive study performed from February to October 2016 on 54 qPCR ZIKV50 positive pregnant women identified by the Public Health Authority of São Jose do Rio Preto, São Paulo, Brazil. The women were followed and had clinical and epidemiological data collected before and after birth. Adverse outcomes in newborns were analyzed and reported. Urine or blood samples from newborns were collected to identify ZIKV infection by RT-PCR.
Results: 216 acute Zika-suspected pregnant women were identified, and 54 had the diagnosis con55 firmed by RT-PCR. None of the 54 women miscarried. Among the 54 newborns, 15 exhibited ad56 verse outcomes at birth. The highest number of ZIKV infections occurred during the second and third trimesters. No cases of microcephaly were reported, though the broad clinical spectrum of outcomes, as lenticulostriate vasculopathy, subependymal cysts, auditive and ophtalmological dis59 orders, were identified. ZIKV RNA was detected in 18 of 51 newborns tested and in eight of 15 newborns with adverse outcomes. Conclusions: Although other studies have associated many newborn outcomes to ZIKV infection during pregnancy, these same adverse outcomes were rare or non-existent in this study. The clinical presentation in our newborns was mild compared to other reports, suggesting that there is significant heterogeneity of Congenital Zika Infection. | |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São Paulo State University. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São Paulo State University. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São Paulo State University. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Evandro Chagas Institute. Ananindeua, PA, Brazil. | pt_BR |
Affilliation | Evandro Chagas Institute. Ananindeua, PA, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Health Secretariat. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brazil / Yale School of Public Health. New Haven, Connecticut, USA. | pt_BR |
Affilliation | Fundacao Oswaldo Cruz. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | University of Texas Medical Branch. Galveston, Texas, USA. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil. | pt_BR |
Affilliation | Yale School of Public Health. New Haven, Connecticut, USA. | pt_BR |
Peer reviewed | Não | pt_BR |
Publication status | Não Publicado | pt_BR |