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ADVERSE BIRTH OUTCOMES ASSOCIATED WITH ZIKA VIRUS EXPOSURE DURING PREGNANCY IN SÃO JOSÉ DO RIO PRETO, BRAZIL
Gravidez
Dengue
Infecção por Zika Virus
Gestantes
Dengue
Saúde Pública
Recem-nascido
Microcefalia
Author
Nogueira, Mauricio Lacerda
Nery Júnior, Nivison Ruy Rocha
Estofolete, Cássia Fernanda
Terzian, Ana Carolina Bernardes
Guimarães, Georgia de Freitas
Zini, Nathalia
Silva, Rafael Alves da
Silva, Gislaine Celestino Dutra
Franco, Ligia Cosentino Junqueira
Rahal, Paula
Bittar, Cintia
Carneiro, Bruno
Costa, Pedro Fernando Vasconcelos da
Henriques, Daniele Freitas
Barbosa, Deusenia Machado Ulisses
Rombola, Patrícia Lopes
Grande, Luciana de
Reis, Andréia Francesli Negri
Palomares, Sacha Ariane
Catelan, Marcia Wakai
Cruz, Lilian Elisa Arão Antonio
Necchi, Silvia Helena
Mendonça, Rita de Cassia Vilella
Santos, Izalco Nuremberg Penha dos
Caron, Suzimeiri Brigatti Alavarse
Costa, Federico
Bozza, Fernando A.
Souza, Antonio Soares de
Mattos, Cinara Cássia Brandão de
Mattos, Luiz Carlos de
Vasilakis, Nikos
Oliani, Antonio Helio
Oliani, Denise Cristina Mós Vaz
Ko, Albert Icksang
Nery Júnior, Nivison Ruy Rocha
Estofolete, Cássia Fernanda
Terzian, Ana Carolina Bernardes
Guimarães, Georgia de Freitas
Zini, Nathalia
Silva, Rafael Alves da
Silva, Gislaine Celestino Dutra
Franco, Ligia Cosentino Junqueira
Rahal, Paula
Bittar, Cintia
Carneiro, Bruno
Costa, Pedro Fernando Vasconcelos da
Henriques, Daniele Freitas
Barbosa, Deusenia Machado Ulisses
Rombola, Patrícia Lopes
Grande, Luciana de
Reis, Andréia Francesli Negri
Palomares, Sacha Ariane
Catelan, Marcia Wakai
Cruz, Lilian Elisa Arão Antonio
Necchi, Silvia Helena
Mendonça, Rita de Cassia Vilella
Santos, Izalco Nuremberg Penha dos
Caron, Suzimeiri Brigatti Alavarse
Costa, Federico
Bozza, Fernando A.
Souza, Antonio Soares de
Mattos, Cinara Cássia Brandão de
Mattos, Luiz Carlos de
Vasilakis, Nikos
Oliani, Antonio Helio
Oliani, Denise Cristina Mós Vaz
Ko, Albert Icksang
Affilliation
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São Paulo State University. São José do Rio Preto, SP, Brazil.
São Paulo State University. São José do Rio Preto, SP, Brazil.
São Paulo State University. São José do Rio Preto, SP, Brazil.
Evandro Chagas Institute. Ananindeua, PA, Brazil.
Evandro Chagas Institute. Ananindeua, PA, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brazil / Yale School of Public Health. New Haven, Connecticut, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
University of Texas Medical Branch. Galveston, Texas, USA.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
Yale School of Public Health. New Haven, Connecticut, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São Paulo State University. São José do Rio Preto, SP, Brazil.
São Paulo State University. São José do Rio Preto, SP, Brazil.
São Paulo State University. São José do Rio Preto, SP, Brazil.
Evandro Chagas Institute. Ananindeua, PA, Brazil.
Evandro Chagas Institute. Ananindeua, PA, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Health Secretariat. São José do Rio Preto, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brazil / Yale School of Public Health. New Haven, Connecticut, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
University of Texas Medical Branch. Galveston, Texas, USA.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
São José do Rio Preto School of Medicine. São José do Rio Preto, SP, Brazil.
Yale School of Public Health. New Haven, Connecticut, USA.
Abstract
Objective: We aimed to report the first 54 cases of pregnant women infected by Zika vírus (ZIKV) and their virological and clinical outcomes, as well as the newborns’ outcomes in 2016, after the emergence of ZIKV in dengue endemic areas of São Paulo, Brazil. Methods: This is a descriptive study performed from February to October 2016 on 54 qPCR ZIKV50 positive pregnant women identified by the Public Health Authority of São Jose do Rio Preto, São Paulo, Brazil. The women were followed and had clinical and epidemiological data collected before and after birth. Adverse outcomes in newborns were analyzed and reported. Urine or blood samples from newborns were collected to identify ZIKV infection by RT-PCR.
Results: 216 acute Zika-suspected pregnant women were identified, and 54 had the diagnosis con55 firmed by RT-PCR. None of the 54 women miscarried. Among the 54 newborns, 15 exhibited ad56 verse outcomes at birth. The highest number of ZIKV infections occurred during the second and third trimesters. No cases of microcephaly were reported, though the broad clinical spectrum of outcomes, as lenticulostriate vasculopathy, subependymal cysts, auditive and ophtalmological dis59 orders, were identified. ZIKV RNA was detected in 18 of 51 newborns tested and in eight of 15 newborns with adverse outcomes. Conclusions: Although other studies have associated many newborn outcomes to ZIKV infection during pregnancy, these same adverse outcomes were rare or non-existent in this study. The clinical presentation in our newborns was mild compared to other reports, suggesting that there is significant heterogeneity of Congenital Zika Infection.
Keywords in Portuguese
Zika VirusGravidez
Dengue
Infecção por Zika Virus
Gestantes
Dengue
Saúde Pública
Recem-nascido
Microcefalia
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